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Structural and functional differences between KRIT1A and KRIT1B isoforms: a f...

Francalanci(Floriana),Avolio(Maria),De Luc... Exp Cell Res 2009-02-11

...Rap1A, while the FERM domain of KRIT1A is even sufficient for this function. Furthermore, we found that a functional PTB...

Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated ...

Wang(Z),Holly(S P),Larson(M K),Liu(J),Yuan... J Thromb Haemost 2009-08-17

...Rap1a and Rap2 activation upon agonist stimulation, possibly revealing functional compensation among Rap family members....

Mutation analysis of RAP1 gene in papillary thyroid carcinomas.

Matsuse(Michiko),Mitsutake(Norisato),Rogou... Endocr J 2009-04-21

...RAP1A or RAP1B genes were found. These results suggest that RAP1 mutation does not play an important role in PTC pathoge...

Activation of Rap1 promotes prostate cancer metastasis.

Bailey(Candice L),Kelly(Patrick),Casey(Pat... Cancer Res 2009-07-06

...Rap1A activity via RNAi-mediated knockdown or ectopic expression of Rap1GAP markedly impaired CaP cell migration and inv...

Zoledronic acid determines S-phase arrest but fails to induce apoptosis in ch...

Romani(Antonello A),Desenzani(Silvia),Morg... Biochem Pharmacol 2009-06-17

...Rap1A prenylation was reversed in cell co-treated with GGOH. At 10-50 microM zoledronic acid exerted an S-phase cell cyc...

JAM-C induces endothelial cell permeability through its association and regul...

Li(Xiaochun),Stankovic(Milena),Lee(Boris P... Arterioscler Thromb Vasc Bi... 2009-08-06

...Rap1a. Thrombin, a powerful inductor of vascular leak, causes localization of JAM-C into the junctions, whereas angiopoi...

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice wit...

Hirbe(Angela C),Roelofs(Anke J),Floyd(Desi... Bone 2009-07-27

...Rap1a proteins in vitro. However, it is presently unclear whether N-BPs exert anti-tumor effects in bone independent of ...

Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-...

Arora(Pamela D),Conti(Mary Anne),Ravid(Sho... Mol Biol Cell 2009-03-10

...Rap1A to filamentous myosin rods, and in situ staining of permeabilized cells showed that NM II-A filaments colocalized ...

The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependen...

Thapliyal(Ashish),Bannister(Roger A),Hanks... Am J Physiol Cell Physiol 2009-01-06

...Rap1A-G12V, Rap2B, Rheb2, or Gem failed to duplicate the effects of AGS1 and Rhes on Ca(V)2.2. Our data provide the firs...

Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate...

Severson(Eric A),Lee(Winston Y),Capaldo(Ch... Mol Biol Cell 2009-07-01

...Rap1A because knockdown of Rap1A, but not Rap1B, resulted in decreased beta1 integrin levels and reduced cell migration....

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