Gentry(Leanna R),Martin(Timothy D),Reiner(... Biochim Biophys Acta 0000-00-00

...RalB, interact with a variety of downstream effectors and have been found to play key and distinct roles in both normal ...

Pawar(Archana),Meier(Jeremy A),Dasgupta(An... Cell Signal 0000-00-00

...RalB could both however activate Arf6. This is further conserved in oncogenic H-Ras containing bladder cancer T24 cells,...

Wan(Zhi Yi),Tian(Johann Shane),Tan(Hayden ... Hepatology 0000-00-00

...RalB abolished FGF19-induced mTORC1 activation, demonstrating that Ral proteins are required for FGF19 to activate mTORC...

Kodama(Takahiro),Bard-Chapeau(Emilie A),Ne... Gastroenterology 0000-00-00

...Ralb. Dual inhibition of Ras signaling via Ral and Raf, using a combination of small-molecule inhibitor RBC8 and sorafen...

Eckfeldt(Craig E),Pomeroy(Emily J),Lee(Rob... Oncotarget 0000-00-00

...RALB signaling in AML survival. Knockdown of RALB led to decreased phosphorylation of TBK1 and reduced BCL2 expression, ...

Thomas(Jemima C),Cooper(Jonathan M),Clayto... J Biol Chem 0000-00-00

...RalB-driven cellular processes. This, therefore, provides a starting point for therapeutic inhibition of the Ras-RalGEF-...

Wong(Richard),Feig(Larry A) Biochem Biophys Res Commun 0000-00-00

...RalB. GTP-bound Ras has the capacity to activate Ral GTPases at least in part by binding to the C-terminal Ras-binding d...

Dharmaiah(Srisathiyanarayanan),Bindu(Laksh... Proc Natl Acad Sci U S A 0000-00-00

...RalB, and Rac1, do not bind to PDEδ. Comparison of all four available structures of PDEδ complexed with various prenylat...

Yan(Chao),Theodorescu(Dan),Miller(Bettina)... Bioorg Med Chem Lett 0000-00-00

...RalB activity in H2122 spheroids using the common RalBP1 pull-down assay. Mouse PK and tissue distribution studies on 40...