...MYCN genes within developing retinal cells. Chemoresistance and metastasis are major challenges for treatment, with the ...
...MYCN. The epigenetic regulator EZH2, a histone methyltransferase of the PRC2 complex, is overexpressed in NB and linked ...
...MYCN amplification and TP53 mutations were independent adverse markers in SHH MB. Group 3 showed the worst survival, wit...
High-risk neuroblastoma (HR-NB) remains a devastating pediatric malignancy characterized by MYCN amplification-induced a...
...MYCN amplification-associated downregulation of MHC-I, and heterogeneity of GD2 antigen expression; (3) host factors, su...
...MYCN). In contrast, amplification of the 12q13-q14 chromosomal region involves a gene-rich region in which there are at ...
...MYCN copy gain/upregulation and chromatin remodeling. ABCB1 expression correlates with interchromosomal enhancer interac...
...MYCN oncogene to enhance NB tumorigenesis and metastasis. To better understand this synergy, we performed single-cell RN...
...MYCN/17q+ tumors compared to MYCN alone. Of these six genes, knockdown of BIRC5, CDC6, IGF2BP1, or TK1 in MYCN/17q+ cell...
...MYCN amplification status. Large ATRX deletions and truncating mutations identify an ultrahigh-risk molecular subtype of...
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