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E2A proteins enhance the histone acetyltransferase activity of the transcriptio…

Hyndman(Brandy D),Thompson(Patrick),Bayly(Ri… Biochim Biophys Acta 2013-04-26

...PBX1. CREB binding protein (CBP) and its close paralog p300 are transcriptional co-activators with intrinsic histone ace...

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.

Denis(Christopher M),Chitayat(Seth),Plevin(M… Blood 2013-01-16

...PBX1 oncoprotein. An interaction involving a region within the N-terminal transcriptional activation domain of E2A-PBX1,...

Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeu…

Hartsink-Segers(S A),Zwaan(C M),Exalto(C),Lu… Leukemia 2013-04-30

...PBX1-translocated ALL cases (P<0.002), compared with normal bone-marrow mononuclear cells. Aurora kinase expression was ...

Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblast…

Cimmino(Luisa),Aifantis(Iannis) Cancer Discov 2013-05-30

...PBX1, and MLL rearrangements. The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL...

Integrative epigenomic analysis identifies biomarkers and therapeutic targets i…

Geng(Huimin),Brennan(Sarah),Milne(Thomas A),… Cancer Discov 2013-05-30

...PBX1 chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq), suggesting that E2A-PBX1 fusion protein directly remode...

The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional r…

Sengupta(M),Liang(S),Potula(H-H S),Chang(L-J… Genes Immun 2013-05-10

...Pbx1. Conversely, Pbx1-d transduction reduced the expression of Sox3, a gene strongly transactivated by Pbx1, and Pbx1-d...

GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acut…

Holmlund(T),Lindberg(M J),Grander(D),Wallber… Leukemia 2013-04-30

...PBX1), resulting in expression of the chimeric transcription factor E2A-PBX1. E2A-PBX1 can promote cell transformation b...

The side population phenomenon enriches for designated adrenocortical progenito…

Lichtenauer(Urs),Shapiro(Igor),Sackmann(Simo… J Endocrinol 2013-01-16

...Pbx1 haploinsufficient mice, suggesting a stem cell deficit. By contrast, the subcapsular zone of ACTH-deficient Tpit(-/...

Rapid detection of prognostically significant fusion transcripts in acute leuke…

Cho(Young-Uk),Chi(Hyun-Sook),Park(Chan-Jeoun… J Korean Med Sci 2013-05-09

...PBX1, ETV6-RUNX1, MLL-AFF1, MLL-MLLT4, MLL-MLLT3, MLL-MLLT10, MLL-ELL, MLL-MLLT1, and MLL-MLLT6. A total of 121 diagnost...

Rational design of an immunoconjugate for selective knock-down of leukemia-spec…

Uckun(Fatih M),Qazi(Sanjive),Dibirdik(Ilker)… Integr Biol (Camb) 2013-06-24

...PBX1(+) B-lineage ALL. Treatment of E2A-PBX1(+) leukemia cells with low nanomolar concentrations of αCD19-AON resulted i...

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