...KRAS, NF1, or CBL-establishing JMML as the prototypical malignant manifestation of RASopathy biology. The fifth edition ...
...KRAS-MAPK and PI3K-AKT. We introduce the concept of PTM remodeling, wherein transient metabolic perturbations become per...
...KRAS) wild-type status (p = 0.001), lymph node metastasis (p = 0.039), and perineural invasion (p = 0.021). Patients wit...
...KRAS-mutant and wild-type tumors; however, KRAS-mutant tumors exhibited differential enrichment of K. rosea and L. bugur...
...KRAS-directed therapies and rational combination strategies. In BTCs, especially intrahepatic cholangiocarcinoma, compre...
...KRAS/JAK cluster and an ETV6::RUNX1 cluster characterized by relative mutational exclusivity, with additional associatio...
...KRAS/RAC1/PIP4K2 axis. Molecular docking results suggested its strong binding affinity and specificity. In vivo studies ...
...KRAS G12D pocket. Conclusions: These findings demonstrate that MPFF-IS can efficiently identify potential KRAS G12D inhi...
...KRAS was identified as a direct target of miR-143-3p. In SNI mouse models, miR-143-3p significantly inhibited KRAS expre...
...KRAS p.G12A driver mutation in all 3 tumor components (MLA, endometrioid adenocarcinoma, and mucinous tumor), indicating...
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