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Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in...

Merrell(Melinda A),Wakchoure(Savita),Ilves... Eur J Pharmacol 2007-04-09

...Rap1A, p38 phosphorylation and growth inhibition in human MDA-MB-231 breast cancer and mouse AB-12 mesothelioma cells. F...

[The X+ chronic granulomatous disease as a fabulous model to study the NADPH ...

Stasia(Marie-José) Med Sci (Paris) 2007-09-12

...Rap1A. Cytochrome b558 consists of two sub-units gp91phox and p22phox. The most common form of CGD is due to mutations i...

Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inh...

Peng(Hairuo),Carrico(Dora),Thai(Van),Blask... Org Biomol Chem 2007-07-11

...Rap1A by PGGTase-I in whole cells with IC(50) values of 0.4 microM and 0.7 microM respectively.

A third-generation bisphosphonate, minodronic acid (YM529), successfully prev...

Sato(K),Yuasa(T),Nogawa(M),Kimura(S),Segaw... Br J Cancer 2007-01-16

...Rap1A in vivo. YM529 administered systemically did not markedly inhibit the growth of visceral metastases but it showed ...

Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit pro...

Maalouf(Mona A),Wiemer(Andrew J),Kuder(Cra... Bioorg Med Chem 2007-05-04

...Rap1a, and Rab6. Similar to their non-fluorescent counterparts, some of these fluorescent isoprenoid bisphosphonates dim...

Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion.

Duchniewicz(Marlena),Zemojtel(Tomasz),Kola... Mol Cell Biol 2006-02-13

...Rap1A gene by homologous recombination. Mice homozygous for the deletion allele are viable and fertile. However, primary...

Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma.

Zhang(Zhaocheng),Mitra(Raj S),Henson(Bradl... Am J Pathol 2006-03-21

...rap1A and rap1B isoforms of rap1 are expressed in SCC, the rap1GAP inactivation of both rap1 isoforms was verified using...

Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of...

Roelofs(Anke J),Hulley(Philippa A),Meijer(... Int J Cancer 2006-09-12

...Rap1A and Rab6, whereas 3-PEHPC only inhibited Rab6 prenylation. Both RIS and 3-PEHPC dose-dependently increased apoptos...

Synthesis and biological activity of isoprenoid bisphosphonates.

Shull(Larry W),Wiemer(Andrew J),Hohl(Raymo... Bioorg Med Chem 2006-08-08

...Rap1a, in human-derived K562 leukemia cells. Most importantly, these compounds impair protein geranylgeranylation and no...

Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involv...

Greco(Fabio),Ciana(Annarita),Pietra(Daniel... Biochim Biophys Acta 2006-06-02

...Rap1a or Rap1b. In RBCs, Rap2 was membrane-associated and was rapidly activated upon treatment with Ca2+/Ca2+ -ionophore...

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