...KRAS mutations. Among the 209 cases with confirmed specific KRAS subtypes, 14 (6.7%, 14/209) presented with uncommon KRA...
...KRAS alterations. These pathways exhibit extensive crosstalk, contributing to therapeutic resistance. This review explor...
...KRAS mutation was identified in one patient. CD74 (n = 5) and SLC3A2 (n = 3) were predominant fusion partners, with sing...
...KRAS proto-oncogene, GTPase (KRAS) (41%), GNAS complex locus (GNAS) (30%), tumor protein p53 (TP53) (30%), and SMAD fami...
...KRAS signaling. We summarize recent advances across KRAS structure and conformations, allelic heterogeneity, and roles i...
...KRAS (45%), and APC (30%) across the histopathologic subgroups. In addition, 6 of 8 high-grade tumors (75%) harbored MDM...
...KRAS mutation frequency. RARRES1 was nominated as a core upregulated gene in this subpopulation. Functional studies conf...
...Kras mutated (Krasmut) KPC mouse tumors, but not WT (KrasWT) Panc02 tumors. The combination of anti-PD-1 antibodies and ...
KRAS mutations are among the most prevalent oncogenic alterations in colorectal, lung and pancreatic cancer, yet their d...
...Kras) G12C mutation and was treated with sotorasib orally in combination with bevacizumab, achieving stable disease and ...
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