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Zoledronic acid treatment impairs protein geranyl-geranylation for biological...

Goffinet(M),Thoulouzan(M),Pradines(A),Lajo... BMC Cancer 2006-04-20

...Rap1A was abolished whereas farnesylation of HDJ-2 was unaffected. Inhibition of Rap1A geranyl-geranylation by ZOL was r...

Identification and biochemical characterization of Rap2C, a new member of the...

Paganini(Simona),Guidetti(Gianni Francesco... Biochimie 2006-07-17

...Rap1A, Rap1B, Rap2A and Rap2B. In this work we report the identification and characterization of a fifth member of this ...

Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhib...

Thompson(Keith),Rojas-Navea(Javier),Rogers... Blood 2006-02-07

...Rap1A in peripheral blood mononuclear cells and macrophages, indicative of inhibition of the mevalonate pathway. Further...

RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac act...

Goldfinger(Lawrence E),Ptak(Celeste),Jeffe... J Cell Biol 2006-11-01

...Rap1A. RLIP76 is required for adhesion-induced Rac activation and the resulting cell spreading and migration, as well as...

Reconstructing and deconstructing agonist-induced activation of integrin alph...

Han(Jaewon),Lim(Chinten James),Watanabe(Na... Curr Biol 2006-10-30

...Rap1A(G12V) bypassed the requirement for PKC, establishing that Rap1 is downstream of PKC. Talin binding to integrins me...

Bisphosphonates inhibit the growth of mesothelioma cells in vitro and in vivo...

Wakchoure(Savita),Merrell(Melinda A),Aldri... Clin Cancer Res 2006-08-21

...Rap1A in these cells. Both these in vitro effects were reversed by geranygeraniol, an end product of the mevalonate path...

Cytosolic entry of bisphosphonate drugs requires acidification of vesicles af...

Thompson(Keith),Rogers(Michael J),Coxon(Fr... Mol Pharmacol 2006-06-26

...Rap1A prenylation, an effect that was reversed by addition of Ca2+. In J774 cells and osteoclasts, vesicular AF-ALN colo...

Rap1 regulates E-cadherin-mediated cell-cell adhesion.

Price(Leo S),Hajdo-Milasinovic(Amra),Zhao(... J Biol Chem 2005-02-15

...Rap1A restored cadherin-mediated cell-cell contacts in mesenchymal Ras-transformed Madin-Darby canine kidney cells, resu...

Mechanism of free radical nitric oxide-mediated Ras guanine nucleotide dissoc...

Heo(Jongyun),Prutzman(Kirk C),Mocanu(Viore... J Mol Biol 2005-03-29

...Rap1A and Rab3A GTPases.

Superoxide anion radical modulates the activity of Ras and Ras-related GTPase...

Heo(Jongyun),Campbell(Sharon L) J Biol Chem 2005-05-13

...Rap1A, to O2* and provide evidence for the efficient guanine nucleotide reassociation in the presence of the radical que...

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