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Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeu…

Hartsink-Segers(S A),Zwaan(C M),Exalto(C),Lu… Leukemia 2013-04-30

...PBX1-translocated ALL cases (P<0.002), compared with normal bone-marrow mononuclear cells. Aurora kinase expression was ...

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.

Denis(Christopher M),Chitayat(Seth),Plevin(M… Blood 2013-01-16

...PBX1 oncoprotein. An interaction involving a region within the N-terminal transcriptional activation domain of E2A-PBX1,...

Clinical features, early treatment responses, and outcomes of pediatric acute l…

Gao(Chao),Zhao(Xiao-Xi),Li(Wei-Jing),Cui(Lei… Am J Hematol 2013-01-03

...PBX1 fusion genes or other B cell precursor ALLs (BCP-ALL) had favorable clinical features, were sensitive to prednisone...

Prognostic significance of FLT3 mutational status and expression levels in MLL-…

Chillón(M C),Gómez-Casares(M T),López-Jorge(… Leukemia 2013-01-24

...PBX1+ B-ALL overexpressed FLT3. In contrast, mainly MLL-AF4+ B-ALL but also ETV6-RUNX1+, BCR-ABL+ or B-ALL displaying no...

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 modul…

Koss(Matthew),Bolze(Alexandre),Brendolan(And… Dev Cell 2012-07-30

...Pbx1 deficiency causes organ growth defects including asplenia. Here, we show that mice with splenic mesenchyme-specific...

Congenital diaphragmatic hernia candidate genes derived from embryonic transcri…

Russell(Meaghan K),Longoni(Mauro),Wells(Juli… Proc Natl Acad Sci U S A 2012-04-12

...Pbx1), and identified a range of previously undetected diaphragmatic defects. Our study demonstrates the utility of gene...

TG-interacting factor (TGIF) downregulates SOX3 gene expression in the NT2/D1 c…

Mojsin(Marija),Popovic(Jelena),Kovacevic Gru… J Genet Genomics 2012-12-10

...PBX1 (pre-B-cell leukemia homeobox 1) and MEIS1 (myeloid ecotropic viral integration site 1 homologue), and the expressi...

Analysis of genomic aberrations and gene expression profiling identifies novel …

Rice(K L),Lin(X),Wolniak(K),Ebert(B L),Berko… Blood Cancer J 2012-10-02

...PBX1). We show that NFIB, which is amplified in 7/87 MPN patients and upregulated in PV CD34+ cells, protects cells from...

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins i…

Dassé(E),Volpe(G),Walton(D S),Wilson(N),Del … Blood Cancer J 2012-10-02

...Pbx1 and Pbx2 bind in vivo to the c-myb locus and maintain its expression through different mechanisms in HPCs and leuke...

The role of Pbx1 in T cells.

Sengupta(Mayami),Morel(Laurence) Protein Cell 2012-05-17

...Pbx1 in tissue differentiation as well as our recent findings associating genetic variations in Pbx1 to lupus susceptibi...

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