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Influence of single-nucleotide polymorphisms on deferasirox C trough levels a...

Cusato(J),Allegra(S),Massano(D),De Francia... Pharmacogenomics J 2016-02-10

...BCRP1). Further aim was to define a plasma concentration cutoff value predicting an adequate response to therapy. Plasma...

Isolation and characterization of a stem cell side-population from mouse hair...

Miliani de Marval(Paula L),Kim(Sun Hye),Ro... Methods Mol Biol 2015-02-23

...BCRP1/ABCG2). In this chapter, we described the isolation of SP stem cells from adult mouse hair follicles utilizing the...

ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhib...

Zhang(Ping),de Gooijer(Mark C),Buil(Levi C... Int J Cancer 2015-11-24

...Bcrp1 restrict the brain penetration of EPZ005687 and GSK126, whereas the brain accumulation of EPZ-6438 is limited by P...

Determination of pharmacokinetics of chrysin and its conjugates in wild-type ...

Ge(Shufan),Gao(Song),Yin(Taijun),Hu(Ming) J Agric Food Chem 2015-10-26

...Bcrp1 -/-) mice. In addition, the role of BCRP in chrysin phase II disposition was further investigated in Caco-2 cells....

The effects of ABCG2 on the viability, proliferation and paracrine actions of...

Liu(Hong-Bao),Meng(Qiu-Hong),Du(De-Wei),Su... Int J Med Sci 2015-03-30

Bcrp1/ABCG2 is exclusively expressed in side population (SP) cells, however, it has not been fully elucidated whether it...

Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: implic...

Vaidhyanathan(Shruthi),Mittapalli(Rajendar... Drug Metab Dispos 2015-02-09

...Bcrp1((-/-)) (triple knockout) mice when compared with wild-type and Bcrp1((-/-)) (Bcrp knockout) mice. The brain distri...

Resistance to daunorubicin, imatinib, or nilotinib depends on expression leve...

Kosztyu(Petr),Bukvova(Romana),Dolezel(Petr... Chem Biol Interact 2015-07-08

...BCRP1, (breast cancer resistance protein 1)) expressions on cell resistance to daunorubicin (DRN), imatinib, and nilotin...

Identification of side population cells in chicken embryonic gonads.

Bachelard(Elodie),Raucci(Franca),Montillet... Theriogenology 2015-09-01

...BCRP1 channel membrane using Verapamil and/or Ko143 showed that P3, but not P4 phenotype, was dependent on BCRP1 activit...

Role of P-glycoprotein on the brain penetration and brain pharmacodynamic act...

Choo(Edna F),Ly(Justin),Chan(Jocelyn),Shah... Mol Pharm 2015-07-14

...Bcrp1 established that cobimetinib was a substrate of P-gp but not a substrate of Bcrp1. In vivo, after intravenous and ...

Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.

Krauze(Aivars),Grinberga(Signe),Krasnova(L... Bioorg Med Chem 2015-07-22

...BCRP1, P-gp, and MRP1 inhibitor activity, and most potent MDR modulators were also screened for their toxicity, cytotoxi...

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