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Whole-exome sequencing identifies new pathogenic germline variants in patient...

Dos Santos(W),Pereira(AS),Laureano(T),de A... World J Gastroenterol 2025-08-07

...FRK gene identified in a patient with classic polyposis at age 19 and with a family history of polyps. This study identi...

CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis.

Du(M),Zhang(X),Cong(M),Cai(C),Zhang(Q),Xin... iScience 2025-07-18

...FRK is a direct target of miR-135b-5p. Finally, a tumor-suppressing role of circYAP1 was demonstrated in the orthotopic ...

Transcriptomic Dynamics of Rice Varieties with Differential Cold Tolerance Un...

Cao(L),Wang(X),Liu(Y),Ding(G),Zhou(J),Lei(... Genes (Basel) 2025-08-11

...FRK, amyA, and TPP) in the starch and sucrose metabolism pathway were significantly upregulated in cold-tolerant varieti...

Genetic variations in TP53 binding sites are predictors of clinical outcomes ...

Lin(Victor C),Huang(Chao-Yuan),Lee(Yung-Ch... Arch Toxicol 2016-05-06

...FRK rs171866 remained as a significant predictor for disease progression; DAB2 rs268091 and EXOC4 rs1149558 remained as ...

The role of dasatinib in the management of chronic myeloid leukemia.

Chen(Runzhe),Chen(Baoan) Drug Des Devel Ther 2016-05-17

...FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase. Various clinical trials have provided evidence that ...

Asymmetric Wnt Pathway Signaling Facilitates Stem Cell-Like Divisions via the...

Mila(Danielle),Calderon(Adriana),Baldwin(A... Genetics 2016-08-23

...FRK-1. Additionally, we observed a significant change in the expression of heterochronic regulators in frk-1(ok760) muta...

Mutations leading to constitutive active gp130/JAK1/STAT3 pathway.

Pilati(Camilla),Zucman-Rossi(Jessica) Cytokine Growth Factor Rev 2016-06-17

...FRK; (3) 5% harbor mutations in STAT3; (4) 5% harbor somatic mutations in the GNAS complex locus; and (5) 1% of IHCA har...

Genome-wide analysis of MAPKKKs shows expansion and evolution of a new MEKK c...

Daigle(Caroline),Matton(Daniel P) BMC Genomics 2016-06-27

...FRK1 and ScFRK2, are involved in male and female reproductive development. Apart from these two kinases, almost nothing ...

Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer's Dis...

Rosenberger(Andrea F N),Hilhorst(Riet),Coa... J Alzheimers Dis 2016-10-28

...FRK). The identified protein kinases are new biomarkers and potential drug targets for early (pre-clinical) intervention...

Phosphotyrosine profiling of curcumin-induced signaling.

Sathe(Gajanan),Pinto(Sneha M),Syed(Nazia),... Clin Proteomics 2016-06-16

...FRK, AXL, MAPK12 and phosphatases such as PTPN6, PTPRK, and INPPL1 among others. Pathway analysis revealed that the prot...

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