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Gut Microbiome, Immune Cells, and Heart Failure: A Multi-Omics Mendelian Rand...

Wei(Y),Ji(X),Mao(Y),Liu(Y),Li(Y) Cardiology 2026-01-23

...HERC5, SUSD3, ZNF292, ZNF655, and DNAJC9 with increased risk of HF, whereas the expression of RMC1, CAMK2G, RPS26, ATP5P...

ISGylation mechanism uncovers conformational specificity for HECT-family E3 l...

Sahoo(P),Parmar(GG),Lenka(DR),Sherawat(M),... Cell Rep 2026-07-28

...HERC5) but is inactive with RING or RBR E3. In contrast, UbcH8∼Ub preferentially engages RBR E3, indicating a switched E...

Restricted MHC-II trafficking in Mycobacterium tuberculosis-infected M2-like ...

Sandhu(AK),Gail(DP),Simmermon(RC),Webb(D),... bioRxiv 2026-07-10

...HERC5, respectively, in infected M2-like monocyte-derived and alveolar macrophages. However, genes involved in MHC-II tr...

Tracing the evolutionary history of small HERCs reveals an unprecedented expa...

Wu(MY),Gong(XY),Guo(WH),Luan(HY),Zhao(ZY),... Fish Shellfish Immunol 2026-09-00

...HERC5/6 and HERC7 appeared in non-mammalian vertebrates instead of HERC5 and HERC6, raising a question of how small HERC...

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discov...

Knol(JC),Lyu(M),Böttger(F),Nunes Monteiro(... Cancer Cell 2025-07-14

...HERC5 (esophageal cancer) and RNF5 (liver cancer). Co-expression analysis reveals 13 modules, including unexpected hub p...

Identification and Validation of ISG15 Target Proteins.

Durfee(Larissa A),Huibregtse(Jon M) Subcell Biochem 2016-04-23

...Herc5, all of which are induced at the transcriptional level by Type 1 interferon signaling. Several proteomics studies ...

Renal involvement in lupus is characterized by unique DNA methylation changes...

Coit(Patrick),Renauer(Paul),Jeffries(Matlo... J Autoimmun 2016-04-18

...HERC5, IFI44, IRF7, ISG15, ISG20, ITGAX, and PARP12 (P = 1.78 × 10(-6)). Among the CG sites only hypomethylated with ren...

Integrative epigenetic profiling analysis identifies DNA methylation changes ...

Weng(Julia Tzu-Ya),Wu(Lawrence Shih-Hsin),... Comput Biol Med 2016-05-25

...HERC5), as well as alcoholism-associated genes ADCY9, CKM, and PHOX2A. Given the limited sample size, our approach uncov...

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 ...

Jacobs(Sarah R),Stopford(Charles M),West(J... J Virol 2016-01-29

...HERC5, which is the major ligase for ISG15, as a vIRF1 binding partner. vIRF1 association with HERC5 altered ISG15 modif...

Inhibition of hepatitis C virus RNA replication by ISG15 does not require it...

Domingues(Patricia),Bamford(Connor G G),Bo... J Gen Virol 2016-05-18

...HERC5. Our results showed that the inhibitory effect of ISG15 on HCV RNA replication does not require its conjugation to...

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