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A positive feedback loop of HK3-mediated activation of NF-κB modulates glucos...

Li(J),Li(J),Liu(N),Chen(L),Zhong(Z),Hu(X),... Int J Biol Macromol 2026-07-00

...HEXB was obviously correlated prognosis in GBM. Then, our attention focused on HK3 which was highly expressed in GBM and...

Novel HEXB variant and first evidence of urinary Gb4 isoforms in Sandhoff dis...

Hammoud(M),Rodrigues(AMS),Assiri(I),Najeh(... Anal Biochem 2026-09-00

...HEXB gene. Lipidomic profiling of urinary extracts demonstrated accumulation of Gb4 and lactosylceramides. This is the f...

Generation and characterization of induced pluripotent stem cell (iPSC) lines...

Jovanovic(VM),Chen(CZ),Toro(C),Hurd(KA),Zo... Stem Cell Res 2026-04-00

Tay-Sachs and Sandhoff diseases, are sphingolipidoses caused by rare genetic mutations in the HEXA and HEXB genes, that ...

Adult-onset Sandhoff disease presenting with a motor neuron disease phenotype...

Tang(Y),Shan(D),Wang(H),Ji(X),Jiao(Y),Li(J... Acta Neuropathol Commun 2026-05-05

Sandhoff disease (SD) is a subtype of GM2 gangliosidosis caused by pathogenic variants in Hexosaminidase B (HEXB). It mo...

Genes Involved in Lipid, Carbohydrate, and Protein Metabolism as Candidates A...

Rando(A),Grassi(G),Perna(AM),Di Gregorio(P... Animals (Basel) 2026-03-25

...HEXB, IGF2, INS, NDUFAB1, PIGC, PNPLA2, PRDX6, SCNN1B, SIAE, SMG1, and UMOD) are also present in the QTL regions affecti...

Light-Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Cr...

Wu(T),Liu(Y),Wang(S),Bai(X),Zhang(L),Liu(Y... Adv Sci (Weinh) 2026-07-00

...HEXB/LAMP1 signaling cascade, suppressing lysosome-multivesicular body fusion and thereby markedly enhancing exosome pro...

Microglia-specificity of different markers is overridden in glioblastoma spec...

Bungert(AD),Sanchin(A),Blank(A),Jüngst-Mie... Sci Rep 2026-05-09

...Hexb that were used for discrimination of populations. In our study, these markers were tested on protein level using im...

The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in mono...

Li(M),Liu(Q),Chen(W),Jiang(F),Song(J),Du(X... Neurotherapeutics 2026-04-00

...HEXB) by upregulating ZFP36, thereby facilitating polarization toward the anti-inflammatory M2 phenotype. Animal experim...

miR-142-3p regulates RDH13 to impair trophoblast function via regulating CDH5...

Shan(L),Lu(K),Zhang(Y),Tao(X),Ma(Y),Fen(S) Front Med (Lausanne) None

...HEXB and RDH13 were identified as potential early biomarkers of preeclampsia diagnosis. Clinically, miR-142-3p was upreg...

Reconstituting central nervous system niche cues partially restores homeostat...

Ilse(V),Barendrecht(S),Hahndorf(J),Geissle... Sci Rep 2026-07-07

...Hexb, Fcrl2, Olfml3, Tgfbr1) within 24 h across isolation methods, with further decline for a subset over 7 days. A cyto...

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