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SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhib…

Wen(T),Yang(L),Cai(S),Liu(Y),Fan(J),Wu(P),Ga… Adv Sci (Weinh) 2026-04-00

...LCN2), an oncoprotein, as a critical downstream target of the SATB2-H3K9la axis. SATB2 is able to bind LCN2 promoter and...

Lipocalin 2: a double-edged sword in cellular ferroptosis.

Xia(Z),Su(X),Xie(L),Zhang(Z),He(Y) Cell Biol Toxicol 2026-02-11

...LCN2 exhibits significant tissue and disease specificity. This is not only attributed to the ability of LCN2 to mediate ...

Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent …

Khanal(V),Carroll(M),Moradi(F),Carter(J),Zho… Cell Death Discov 2026-02-25

...Lcn2 does not alter systemic energy balance, underscoring LCN2's local skeletal function. These findings define the LCN2...

Lcn2 deficiency leads to long-lasting social impairments independent of materna…

Pekala(M),Zawiślak(S),Romanis(S),Nader(K),Dz… J Neuroinflammation 2026-02-25

...Lcn2 mRNA was expressed in the fetal brain and that MIA significantly upregulated Lcn2 mRNA in the hippocampus and neoco...

Evidence for a Cytokine-Sensitive Network of Iron-Associated Genes That Protect…

Slepchenko(KG),Counts(GP),Sharma(PR),Chen(S)… Metabolites 2026-02-04

...Lcn2. These proteins are all involved with increasing/retaining cellular iron. We hypothesized that increased cellular i...

Identification of key hub genes in spinal cord ischemia-reperfusion injury via …

Gao(M),Liu(H),Sun(C),Yuan(J),Wang(L),Ma(J) Sci Rep 2026-02-10

...Lcn2, and Akap12 at 1 h; and delayed up-regulation of Itga5 at 48 h (P < 0.05). This study identifies novel, key SCII-re...

Evaluation of LCN2 and miR-8078 as diagnostic biomarkers for congenital heart d…

Chen(Q),Zheng(D),Zhang(W),Hua(Y),Wang(W),Hua… ESC Heart Fail 2026-02-03

...LCN2 alone. Univariate regression analysis identified both LCN2 and miR-8078 as significant predictors of CHD-PAH. LCN2 ...

The integrated stress response promotes immune evasion through lipocalin 2.

Bossowski(JP),Pillai(R),Kilian(J),Wong Lau(A… Nature 2026-04-00

...LCN2) as the principal ATF4-dependent effector that impairs anti-tumour immunity by favouring infiltration with immunosu...

Inflammatory characteristics induced by cellular senescence in the junctional e…

Sunaga(M),Yukimori(A),Tanaka(J),Aizawa(R),Ok… J Oral Biosci 2026-02-00

...Lcn2, and Defb3 in the JE of aged mice. Immunostaining also revealed increased numbers of γ-H2AX, p-STAT3, 8-OHdG, and 4...

Lipocalin-2 deficiency attenuates kainic acid-induced hippocampal cell death in…

Shin(HJ),Kim(KE),An(HS),Sun(Y),Oh(J),Park(J)… Metab Brain Dis 2026-02-09

...LCN2 knockout (LCN2KO) mice, we found that LCN2 deficiency improved systemic insulin sensitivity and alleviated hepatic ...

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