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Malic Enzyme 1 Limits Acetaminophen-Induced Liver Injury by Sustaining Redox an…

Guo(C),Tang(Z) Metabolites 2026-06-16

...ME1 to APAP-induced liver injury (AILI), we used hepatocyte-specific ME1 knockout mice, hepatic overexpression and recon...

Integrated Multi-Omics and Experimental Validation Reveal Dysregulation of the …

Wu(D),Zhao(J),Chang(X),Lei(Y),Mu(C),Yang(D),… FASEB J 2026-05-31

...ME1, ME2, and IDH1. These changes were accompanied by decreased NADPH availability, imbalance of the glutathione redox s...

Diatomaceous Earth-Enabled Resveratrol Microemulsion for Enhanced Permeation an…

Weerapol(Y),Manmuan(S),Yammen(S),Werayachank… Mar Drugs 2026-04-28

...ME1) and 2:5:3 (ME2) were selected for resveratrol loading and subsequently combined with DE at ratios of DE:microemulsi...

Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acu…

Zhang(T),Zou(R),Chen(Z),Li(Y),Sun(X),Sun(X) Phytomedicine 2026-05-00

...Me1 axis to promote lipid metabolism. Whole transcriptome analysis revealed that 5-O intervention was associated with up...

Integrated bioinformatics analysis and experimental validation of SRF as a pote…

Li(M),Gao(C),Shi(Y),Peng(W),Yin(Y),Lu(B),Fu(… Front Mol Biosci None

...ME1, and GADD45G were determined to be key genes. Experimental validation demonstrated significantly downregulated expre...

Critical Role for Malic Enzymes in MYC-Mediated Cellular Adaptation to Glutamin…

Si(Y),Li(W),Chen(Y),Yuan(J),Hu(C),Liu(Y),Li(… Metabolites 2026-04-20

...ME1 maintains redox balance by generating NADPH, and antioxidant treatment rescues the survival defect caused by ME1 kno...

Antimicrobial and antioxidant activities of Tetracera macrophylla Hook.f. & Tho…

Ahmed(QU),Ab Rahim(MAH),Arzmi(MH),Uddin(AH),… Nat Prod Res 2026-04-11

...ME1, ME2]), among which ME2 exhibited the strongest bioactivity. ME2 showed high total phenolic content (TPC: 254.96 ± 0...

In Vitro Cytotoxic Activity of Coleus hadiensis Methanolic Extract: Metabolic a…

Valdez-Arellanes(AL),Ramírez-Cabrera(MA),Arr… Molecules 2026-03-25

...ME1 correlated with the observed increase in pyruvate levels, while the downregulation of ALDH7A1 and ASRGL1 was linked ...

The Effects of Substituting BHT with a Microencapsulated Basil (Ocimum campechi…

Borges do Vale(R),Coelho Barros(A),Maciel(IJ… Foods 2026-04-03

...ME1 and ME2, respectively). The extracts were analyzed for their antimicrobial activity, antioxidant capacity, and pheno...

Targeting ME1 rescues redox-metabolic coordination in ALS: A core effector of N…

Yang(Y),Yang(Y),Zhang(X),Ma(H),Ji(S),Zou(F),… Neuropharmacology 2026-08-01

...ME1). Loss-of-function experiments confirmed that ME1 knockdown abolished the protective effects, indicating that the NR...

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