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The Rab3 family proteins in age-related neurodegeneration: unraveling molecul...

He(H),Ai(R),Fang(EF),Palikaras(K) NPJ Aging 2025-07-14

...Rab3a, Rab3b, Rab3c, and Rab3d, termed Rab3s. They play crucial roles in health, including in brain function, such as th...

ER-endosome contacts generate a local environment promoting phagophore format...

Da Graça(J),Thiola(C),Rouabah(M),Guerrera(... Cell Rep 2025-07-22

...Rab3a-RAB3GAP1/2-mediated nano-vesicle fusion. We propose that EERCS mobilization generates transient cytoplasmic confin...

Signalling pathways and cellular functions of KDEL receptors: implications in...

Dufrusine(B),Cela(I),Gramegna Tota(C),Palu... Cell Mol Life Sci 2025-08-06

...Rab3a that are mediated respectively by the α-subunits Gαs, Gαq, and Gαo of heterotrimeric G-proteins. KDELR-activated s...

Neurodevelopmental disorder mutations in the exchange factor DENN/MADD disrup...

Khan(M),Kumar(R),Trempe(JF),Francis(V),Ban... J Biol Chem 2025-10-00

...Rab3A, Rab3B, Rab3C, Rab3D, and Rab27B and identified four new potential substrates, Rab8B, Rab15, Rab26, and Rab37, res...

Reversal of age-associated cognitive deficits is accompanied by increased pla...

Li(Yan),Abdourahman(Aicha),Tamm(Joseph A),... Pharmacol Biochem Behav 2016-04-12

...Rab3a). Neither drug reversed the age-associated decrease in stem cell proliferation. Hippocampal growth factor levels w...

Effects of simulated microgravity on the expression of presynaptic proteins d...

Wang(Yun),Iqbal(Javed),Liu(Yahui),Su(Rui),... Proteomics 2016-09-21

...rab3A and its effector rim2. Both processes are disturbed, indicating that presynaptic proteins mediate a GABA/Glu imbal...

Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocam...

Zhou(Jian),Liu(Zhao),Yu(Jia),Han(Xin),Fan(... Int J Neuropsychopharmacol 2016-10-05

...Rab3a and Munc18-1 appear to coregulate syntaxin-1/SNAP25/VAMP2 assembly at the hippocampal presynaptic active zone of u...

Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Perfor...

Mitra(Shiladitya),Sameer Kumar(Ghantasala ... Front Mol Neurosci 2016-09-14

...RAB3A, CAMK2A etc. accompanied with increased spine density of hippocampal CA1 neurons and better spatial memory in mice...

Secretion-related structures of hypothalamo-hypophysial terminals in the rat ...

Takeuchi(Yoshiki),Liu(Jun-Qian),Matsumoto(... Okajimas Folia Anat Jpn 2015-04-13

...Rab3A-siRNA were made into the hypothalamus, respectively. Additional injection of WGA-HRP was made into the hypothalamu...

3D structure generation, virtual screening and docking of human Ras-associate...

Lodhi(Sharad S),Farmer(Rohit),Singh(Atul K... Mol Biol Rep 2015-02-13

Rab3A is expressed predominantly in brain and synaptic vesicles. Rab3A is involved specifically in tethering and docking...

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