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Involvement of RalB in the effect of geranylgeranyltransferase I on glioma ce...

Song(X),Hua(L),Xu(Y),Fang(Z),Wang(Y),Gao(J... Clin Transl Oncol 2016-03-23

...RalB) have effect on glioma cell migration and invasion.,We found that knockdown of GGTase-I or RalB both significantly ...

The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with t...

Popovic(Milica),Schouten(Arie),Rensen-de L... J Struct Biol 2016-11-03

...RalB. Here the crystal structure of Rlf in complex with Ral is determined. The Rlf·Ral complex crystallised into two dif...

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras ...

Vasseur(Romain),Skrypek(Nicolas),Duchêne(B... Biochim Biophys Acta 2016-02-04

...RalB GTPase. Altogether, these results identify MUC4 as a transcriptional and post-transcriptional target of K-ras in pa...

RAL-1 controls multivesicular body biogenesis and exosome secretion.

Hyenne(Vincent),Apaydin(Ahmet),Rodriguez(D... J Cell Biol 2016-02-02

...RalB are both required for the secretion of exosome-like vesicles in cultured cells. Therefore, Ral GTPases represent ne...

RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and supp...

Zhang(Yi),Song(Xilin),Gong(Weipeng),Zhu(Zh... Cell Biochem Biophys 2016-04-21

...RalB, is known to play a role in biological activities in a variety of malignant cancer cells. However, little study has...

Contributions of KRAS and RAL in non-small-cell lung cancer growth and progre...

Guin(Sunny),Ru(Yuanbin),Wynes(Murry W),Mis... J Thorac Oncol 2015-01-09

...RALB expression was associated with poor survival. In a panel of 14 human NSCLC cell lines, RALA and RALB had higher exp...

Thermodynamic mapping of effector protein interfaces with RalA and RalB.

Campbell(Louise J),Peppa(Maria),Crabtree(M... Biochemistry 2015-04-08

...RalB-RLIP76 and RalB-Sec5 complexes reveals mutations in RalB that lead to differential binding of the two effector prot...

Divergent roles of CAAX motif-signaled posttranslational modifications in the...

Gentry(Leanna R),Nishimura(Akiyuki),Cox(Ad... J Biol Chem 2015-12-04

...RalB but not RalA protein. Finally, palmitoylation was critical for subcellular localization of RalB but not RalA. In su...

KRAS oncogene substitutions in Korean NSCLC patients: clinical implication an...

Kim(Eun Young),Kim(Arum),Kim(Se Kyu),Kim(H... Lung Cancer 2015-07-09

...RalB, did not differ between transversion and transition mutants, however, strong expression of RalB in the tissue of pa...

An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor speci...

Tal(Yair),Yaakobi(Shlomo),Horovitz-Fried(M... Oncotarget 2015-08-31

...RalB), as effectors of the proto-oncogene Natural killer (NK) cells are an important component of the anti-tumor respons...

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