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ER stress-driven unfolded protein response fuels aging-related tumor aggressi...

Shao(X),Guo(S),Yang(J),Dai(J),Cao(K),Cai(X... Front Mol Biosci 2025-00-00

...RPN2, SEC13, SEC61A1, SEC61B, and STT3A. Notably, glioma cell proliferation critically depends on ESURATAG-GS, which is ...

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoel...

Lee(K),Negi(H),Chen(X),Atallah-Yunes(K),Tr... bioRxiv 2025-08-02

...RPN2/PSMD1 and RPN13/ADRM1, ideally located to reduce substrates prior to proteolysis. We also resolved chaperone PSMD5 ...

Structure of the TXNL1-bound proteasome.

Gao(J),Nardone(C),Yip(MCJ),Chino(H),Gu(X),... Nat Struct Mol Biol 2025-12-00

...Rpn2), PSMD4 (Rpn10) and PSMD14 (Rpn11). Proteasome binding is necessary for the ubiquitin-independent degradation of TX...

S100A16 knockdown reduces RPN2 expression and inhibits β-catenin/TCF signalin...

Hsin(MC),Wang(PH),Chen(PN),Hsieh(YH),Yang(... Biochim Biophys Acta Mol Ce... 2025-12-00

...RPN2). Furthermore, RPN2 knockdown alone effectively suppressed cell migration and overexpression of S100A16 reversed th...

Structural basis of K11/K48-branched ubiquitin chain recognition by the human...

Draczkowski(P),Chen(SN),Chen(T),Wang(YS),S... Nat Commun 2025-10-15

...RPN2 and RPN10 in addition to the canonical K48-linkage binding site formed by RPN10 and RPT4/5 coiled-coil. Additionall...

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-sm...

Fujita(Yu),Yagishita(Shigehiro),Takeshita(... Oncotarget 2016-03-28

...RPN2 in non-small-cell lung cancer (NSCLC) remain unknown. Here, we examined RPN2 expression in tumor specimens from rec...

Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processin...

He(Jinshan),Zhu(Qianzheng),Wani(Gulzar),Sh... J Biol Chem 2016-08-15

...RPN2, and Sug1 in the chromatin compartment. Surprisingly, both biochemical inhibition and genetic defect of VCP/p97 enh...

Microarray gene expression analysis of tumorigenesis and regional lymph node ...

Lian(Meng),Fang(Jugao),Han(Demin),Ma(Hongz... PLoS One 2015-02-23

...RPN2 were most frequently differently expressed functional genes related to regional lymph node metastasis in LSCC. The ...

A novel platform to enable inhaled naked RNAi medicine for lung cancer.

Fujita(Yu),Takeshita(Fumitaka),Mizutani(Ta... Sci Rep 2015-12-18

...RPN2-PnkRNA), which has been selected as a therapeutic target for lung cancer, resulted in efficient inhibition of tumor...

Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMG...

Zhang(Jialing),Yan(Bin),Späth(Stephan Stan... Cell Biosci 2015-09-21

...RPN2, HMGB1, AARS, IGFBP3, STAT1, HYOU1, NQO1 and PEA15 that were associated with the progressive phenotype. In particul...

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