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Reproduction and immunity-driven natural selection in the human WFDC locus.

Ferreira(Zélia),Seixas(Susana),Andrés(Aida M… Mol Biol Evol 2013-09-03

...SEMG1, which may alter the proteolytic profile of SEMG1 and antimicrobial activities of semen. All the well-characterize...

Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive …

Marques(Patrícia Isabel),Bernardino(Rui),Fer… Genome Biol Evol 2013-05-20

...SEMG1 and SEMG2). Our findings support the placement of the KLK2-KLK3 duplication in the Catarrhini ancestor and unveil ...

Characterization of EPPIN's semenogelin I binding site: a contraceptive drug ta…

Silva(Erick J R),Hamil(Katherine G),Richards… Biol Reprod 2013-03-06

...SEMG1) during ejaculation. Here, we identify EPPIN's amino acids involved in the interactions within the EPC and demonst...

Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor.

O'Rand(Michael G),Widgren(Esther E) Biol Reprod 2012-07-09

...SEMG1 or anti-EPPIN antibodies. Thimerosal can rescue the effects of SEMG1 on motility, implying that internal stores of...

Genes encoding WFDC- and Kunitz-type protease inhibitor domains: are they relat…

Lundwall(Åke),Clauss(Adam) Biochem Soc Trans 2012-01-17

...SEMG1 (semenogelin I) and SEMG2, and 14 genes containing the sequence motif that is characteristic of WFDC-type protease...

Evaluation of mRNA-based approach for identification of saliva and semen.

Sakurada(Koichi),Ikegaya(Hiroshi),Fukushima(… Leg Med (Tokyo) 2010-01-26

...SEMG1), those selected for semen, showed high specificity to these body fluids. Thus, the sensitivity and specificity of...

Analysis of recombinant human semenogelin as an inhibitor of human sperm motili…

Mitra(Anurag),Richardson(Richard T),O'Rand(M… Biol Reprod 2010-06-07

...SEMG1). During ejaculation the presence of semenogelin inhibits sperm progressive motility until semenogelin is hydrolyz...

Hominoid seminal protein evolution and ancestral mating behavior.

Carnahan(Sarah J),Jensen-Seaman(Michael I) Am J Primatol 2008-11-14

...SEMG1 and SEMG2), which code for the predominant proteins in semen. Patterns of nucleotide variation and inferred protei...

Sexual selection and the adaptive evolution of mammalian ejaculate proteins.

Ramm(Steven A),Oliver(Peter L),Ponting(Chris… Mol Biol Evol 2008-07-16

...SEMG1 and SEMG2. Although SEMG2 also shows evidence of positive selection concentrated in lineages subject to high level...

A locus on chromosome 20 encompassing genes that are highly expressed in the ep…

Lundwall(Ake) Asian J Androl 2007-09-06

...SEMG1) and semenogelin II (SEMG2) are degraded to low molecular mass fragments by kallikrein-related peptidase 3 (KLK3),...

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