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scOPE identifies which driver-associated expression programs transfer from bu...

Ashford(AJ),Lapadat(A),Demir(E) bioRxiv 2026-08-12

...KRAS (0.944). Determining which programs transfer therefore becomes the central task. We address it with a ground-truth-...

Pharmacological blockade of oncogenic MAPK activators drives resistance to cy...

Noda(T),Shirahama(H),Tani(Y),Tomida(A) Biochem Biophys Res Commun 2026-09-24

...KRAS, or BRAF drove resistance to cystine deprivation-induced ferroptosis in cancer cells harboring each driver mutation...

Combined inverted follicular keratosis and adnexal tumors: a series of 12 cases.

Daruish(M),Gadeyne(L),Bonenfant(C),Taibjee... Virchows Arch 2026-08-03

...KRAS mutations in 3 of the 4 cases harboring a sebaceous component and also in the specimen with combined IFK and tubula...

Clinicopathological Features and Outcomes of Metastatic Colorectal Cancers Tr...

Natti(HS),Gumdal(V),Koppaka(D),Nuguri(S),P... J Assoc Physicians India 2026-07-00

...KRAS) mutations were detected in 20.7% of patients, whereas microsatellite instability-high (MSI-high) status was identi...

Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected...

Witz(A),Conroy(T),Lambert(A),Salleron(J),D... J Clin Oncol 2026-08-03

...KRAS-mutated patients, mFFX significantly improved DFS compared with GEM (sHR, 0.60 [95% CI, 0.45 to 0.79]; P < .001), w...

Induction of cuproptosis via targeting mitochondrial metabolism using dPTBD w...

Sun(Y),Song(M),Ding(W),Liu(Q),Lu(W),Luo(B)... Cancer Lett 2026-08-03

...KRAS-driven cancer via a tetracycline-inducible cell-based drug screening. dPTBD exhibited significant antitumor efficac...

Discovery of Pan-TEAD Inhibitors That Disrupt YAP-TEAD Interaction as a Poten...

Kumar(R),Thian(J),Toh(JDW),Farzana(N),Sun(... ACS Med Chem Lett 2026-03-12

...KRAS mutant Non-Small Cell Lung Cancer (NSCLC) cells, which may eventually overcome drug resistance associated with the ...

Novel Macrocyclic Compounds Targeting KRAS Mutations for Cancer Treatment.

Meng(L),Liang(SH) ACS Med Chem Lett 2026-03-12

...KRAS oncogene, which is the most frequently mutated in human cancers. These compounds, along with their pharmaceutical c...

Design, Synthesis, and Biological Evaluation of Novel 1H‑Imidazo[4,5-g]quinaz...

Huang(X),Huang(J),Hong(Q),Ou(X),Li(R),Zong... ACS Med Chem Lett 2026-03-12

...KRAS reactivation. SOS1, a key guanine nucleotide exchange factor involved in KRAS activation and implicated in various ...

Deceased Donor Liver Transplantation and Postoperative Survival in Patients w...

Hill(AL),Cullinan(DR),Ahmed(O),Wesson(R),S... J Am Coll Surg 2026-08-01

...KRAS mutation was statistically significantly associated with recurrence (p = 0.01). Transplant was performed a median o...

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