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VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specificatio…

Yang(Y),Jia(W),Luo(Z),Li(Y),Liu(H),Fu(L),Li(… Nat Commun 2024-01-17

...TEAD4 (TEA domain transcription factor 4) to regulate chromatin accessibility at target gene loci through histone acetyl...

Mechanosensor YAP orchestrates human neural rosette morphogenesis via TEAD4-LEF…

Hu(J),He(Z),Hu(H),Sun(X),Che(S),Sun(S),Ma(M)… Sci China Life Sci 2025-11-27

...TEAD4 complex transcriptionally activated LEF1, a central regulator of Wnt signaling. LEF1 deficiency phenocopied YAP lo...

Chemical Space Overlap with Critical Protein-Protein Interface Residues in Comm…

Si(Y),Xu(D),Bum-Erdene(K),Ghozayel(MK),Yang(… ChemMedChem 2019-00-08

...TEAD4⋅Yap1. Virtual screening of conformationally restricted compounds targeting uPAR⋅uPA and TEAD4⋅Yap1 followed by exp...

Wnt3a disrupts GR-TEAD4-PPARγ2 positive circuits and cytoskeletal rearrangement…

Park(B),Chang(S),Lee(GJ),Kang(B),Kim(JK),Par… Cell Death Dis 2019-00-08

...TEAD4 requires GR for its expression and for the ability to bind its own promoter and the hotspot region of Pparg2 gene ...

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interfac…

Scalvini(L),Tagliazucchi(L),Elisi(GM),Zappat… Eur J Med Chem 2025-12-15

The transcriptional activity of TEAD4 (transcriptional enhancer associated domain proteins), one of the final effectors ...

The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hyp…

Petrou(IG),Nikou(S),Madduri(S),Nifora(M),Bra… Cells 2022-00-29

...TEAD4, ILK and a-SMA expression were evaluated by immunohistochemistry in keloids (n = 55), hypertrophic scars (n = 38) ...

Defining a TFAP2C-centered transcription factor network during murine peri-impl…

Gao(R),Yang(G),Wang(M),Xiao(J),Yi(S),Huang(Y… Dev Cell 2024-00-06

...TEAD4 and KLF5 function to mediate cell polarization. Notably, we found that maternal retinoic acid metabolism regulates...

Interpreting regulatory mechanisms of Hippo signaling through a deep learning s…

Dalal(K),McAnany(C),Weilert(M),McKinney(MC),… Cell Genom 2025-04-09

...TEAD4/YAP1 binding in a nucleosome-range and distance-dependent manner, driving synergistic enhancer activation. We also...

VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated…

Chen(Y),Wang(X),Yu(W),Gong(M),Lu(Y),Xu(J),Zh… EMBO Rep 2026-09-22

...TEAD4 and CEBPA and promotes the cooperative activation of Pdk4 expression. Functional studies identify PDK4 as a downst...

A regulatory circuitry driving a noradrenergic to mesenchymal transition highli…

Gautier(M),Kramdi(A),Louis-Brennetot(C),Pier… Cell Rep 2026-05-26

...TEAD4 redistribution and super-enhancer rewiring. These findings reveal a YAP/TAZ-TEAD4 axis controlling tumor cell plas...

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