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Astragalus polysaccharide-containing 3D-printed scaffolds promote cartilage r...

Du(W),Wang(Z),Zeng(W),Hu(H),Tang(Y),Cao(G)... J Mater Chem B 2025-07-10

...Col2a1 and Biglycan was detected by immunofluorescence. Newly formed cartilage tissues were collected for metabolomics a...

Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage de...

Kang(X),Liu(W),Ma(X),Feng(D),Sun(H),Wu(S) Autophagy 2025-12-00

...COL2A1: collagen, type II, alpha 1; DMM: destabilizing the medial meniscus; DMXAA: 5.

Pathogenicity effects of a COL2A1 missense mutation (c.1594G>C) in cartilage ...

Zhou(J),Yuan(T) Transl Pediatr 2025-07-31

...COL2A1 gene. The identified COL2A1 mutation (p.Glu532Gln) may lead to disrupted collagen structure and secretion, contri...

Mesenchymal Stem Cell Protection and Chondrogenic Differentiation in Tracheal...

Shi(L),Ji(W),Zheng(Q),Chen(X),Shen(H),Zhan... ACS Appl Mater Interfaces 2025-07-02

...COL2A1), and aggrecan (ACAN). Strikingly, the combination of SHA-PtNPs and ADSCs achieved 100% healing by day 14 and fac...

Integrative multi-omic analysis of NLRP3 inflammasome dysregulation and subty...

Zhang(H),Yang(L),Liu(Y),Wang(D),Shi(L),Tia... Discov Oncol 2025-07-02

...COL2A1, ITGB2, and SRC genes, providing a comprehensive assessment of patient risk stratification. We revealed a positiv...

Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhi...

Guan(W),Yuan(F),Wang(X) Sci Rep 2025-08-12

...COL2A1, ACSL4, and MMP13. Furthermore, the scTenifoldKnk algorithm was applied to perform a virtual knockout of PPARγ ba...

PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dy...

Chen(F),Peng(F),Chen(S),Du(Y),Li(J),Fan(Y)... Adv Sci (Weinh) 2025-10-00

...Col2a1-CreERT; Piezo1flox/flox) and pharmacological blockade significantly decelerate scoliosis progression. However, os...

Diagnostic Challenge of Phenotypic Variability in COL2A1-related Disorders: F...

Yeter(B),Kendir Demirkol(Y),Eser(M),Akgüll... J Clin Res Pediatr Endocrin... 2025-08-22

Heterozygous COL2A1 gene mutations are associated with type 2 collagenopathies, characterized by a wide, diverse, and ov...

Targeting Ferroptosis With Ginsenoside Rg3 Alleviates Intervertebral Disc Deg...

Xu(W),Geng(F),Zhang(K),Wang(Y) Orthop Surg 2025-10-00

...COL2A1/ACAN/ADAMTS5/MMP3) and ferroptosis markers (GPX4/FTH-1/ACSL4), followed by determination of optimal Rg3 concentra...

Collagen proteins, thrombospondin 1 and lumican are differentially expressed ...

Ku(WC),Phan(NN),Liu(CY),Huang(CJ),Liao(CC)... Biochem Biophys Rep 2025-12-00

...COL2A1, COL11A1, COL6A1, COL6A2, THBS1 and LUM. Public domain databases also showed that COL2A1, COL11A1, COL6A1, COL6A2...

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