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Fluorescence resonance energy transfer (FRET)-based subcellular visualization o…

Buntru(Alexander),Zimmermann(Timo),Hauck(Chr… BMC Biol 2010-01-15

...Hck (Hck-SH2) was not recruited, even though bacteria still bound to the receptor. FRET measurements on the basis of who...

c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.

Baruzzi(Anna),Iacobucci(Ilaria),Soverini(Sim… FEBS Lett 2010-01-21

...Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta1 integrin-bound Hck or c-Fgr in ...

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce…

Yago(Tadayuki),Shao(Bojing),Miner(Jonathan J… Blood 2010-08-20

...Hck and Lyn as well as Fgr. We identified the Tec kinase Bruton tyrosine kinase as a key signaling intermediate between ...

Identification of therapeutic targets for quiescent, chemotherapy-resistant hum…

Saito(Yoriko),Kitamura(Hiroshi),Hijikata(Ats… Sci Transl Med 2010-06-21

...HCK. These molecules are also promising targets for LSC-specific therapy.

PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate Fcepsi…

Samayawardhena(Lionel A),Pallen(Catherine J) J Immunol 2010-12-02

Mast cell activation via FcεRI involves activation of the Src family kinases (SFKs) Lyn, Fyn, and Hck that positively or...

Multidomain assembled states of Hck tyrosine kinase in solution.

Yang(Sichun),Blachowicz(Lydia),Makowski(Lee)… Proc Natl Acad Sci U S A 2010-10-07

...Hck, a member of the Src-family kinases, under various conditions in solution. First, a basis set comprising a small num...

Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, …

Khan(Samina Y),McLaughlin(Nathan J D),Kelher… Biochem J 2010-12-06

...Hck (haemopoietic cell kinase; Tyr⁴¹¹). Moreover, G2A recruited clathrin, β-arrestin-1 and GRK6: clathrin is important f...

Kinetic mechanism and inhibitor characterization of WNK1 kinase.

Yagi(Yukiko I),Abe(Koichi),Ikebukuro(Kazunor… Biochemistry 2009-11-17

...Hck, Lck, and Src inhibitors, PP1 and PP2, exhibited positive inhibition against WNK1. The inhibition mode of PP1 was an...

Mechanisms of deoxynivalenol-induced gene expression and apoptosis.

Pestka(J J) Food Addit Contam Part A Chem… 2009-12-02

...Hck and PKR contribute to DON-induced gene expression and apoptosis. PKR, Hck and other kinases bind to the ribosome and...

Mapping the conformational transition in Src activation by cumulating the infor…

Yang(Sichun),Banavali(Nilesh K),Roux(Benoît) Proc Natl Acad Sci U S A 2009-03-26

...Hck. The information from a large number (78) of independent all-atom molecular dynamics trajectories with explicit solv...

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