...KRAS-mutated, metastatic pancreatic ductal adenocarcinoma (PDAC). This investigator-led, single-arm, open-label, phase I...
...KRAS (6.25%), MTOR (12.5%), PIK3CA (6.25%), AKT2 (6.25%), LARP4B (6.25%), and ACSL6 (6.25%). Copy number alterations wer...
...KRAS mutations. These findings demonstrated that codon-specific KRAS mutations affect PDAC outcomes differently based on...
...KRAS (10.29%), and PIK3CA (9.12%) were the most frequently altered genes. Epstein-Barr virus-positive tumors exhibited e...
...KRAS mutations, are commonly detected in adults; PanIN rarely progresses to invasive PDAC. The molecular mechanisms that...
...KRAS G12C inhibitors have failed to demonstrate significant preclinical single-agent activity. Daraxonrasib (RMC-6236), ...
...KRAS mutations were identified in 73.1% of sequenced cases, predominantly at codon 12. EUS-guided FNB samples can suppor...
...KRAS, IL-8, Caspase-8, PD-1 and PDL-1 in CRC, which were successfully treated with MSN-PEG@Artemisinin and standard Gemi...
...KRAS-associated gene expression. We analyzed transcriptomic data from the TCGA-LGG cohort and public RNA-seq datasets to...
...KRAS mutation conferred an inferior effect on OS and RFS but not CRc. These findings suggest that KRAS mutations may con...
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