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Phase I trial of binimetinib plus hydroxychloroquine in patients with previou...

Haldar(SD),Saj(F),Hong(SJ),Surana(R),Xiao(... Oncologist 2026-03-09

...KRAS-mutated, metastatic pancreatic ductal adenocarcinoma (PDAC). This investigator-led, single-arm, open-label, phase I...

Genomic landscape of pediatric germ cell tumors reveals oncogenic mutations a...

Galvão(JMS),Bezerra(AFSP),Garcia(FAO),Sant... Front Oncol None

...KRAS (6.25%), MTOR (12.5%), PIK3CA (6.25%), AKT2 (6.25%), LARP4B (6.25%), and ACSL6 (6.25%). Copy number alterations wer...

Prognostic Implications of Codon-Specific KRAS Mutations in Localized and Adv...

Raji(S),Zaribafzadeh(H),Jones(T),Kanu(E),T... JCO Precis Oncol 2026-02-00

...KRAS mutations. These findings demonstrated that codon-specific KRAS mutations affect PDAC outcomes differently based on...

Real-World Genomic Landscape of Korean Gastric Cancer: Integrating Biomarker ...

Yoo(SK),Ahn(S),Hwang(J),Kim(J),Go(Y),Kwon(... JCO Precis Oncol 2026-02-00

...KRAS (10.29%), and PIK3CA (9.12%) were the most frequently altered genes. Epstein-Barr virus-positive tumors exhibited e...

PPARδ: An underappreciated tumor accelerator in pancreatic ductal adenocarcin...

Niu(D),Wei(D),Liu(Y),Yao(JC),Shureiqi(I),Z... Cancer Lett 2026-05-01

...KRAS mutations, are commonly detected in adults; PanIN rarely progresses to invasive PDAC. The molecular mechanisms that...

Daraxonrasib (RMC-6236) is an effective targeted therapy for RAS -mutant neur...

Hill(RD),Dalton(KM),Kurupi(R),Slaughter(JM... bioRxiv 2026-02-20

...KRAS G12C inhibitors have failed to demonstrate significant preclinical single-agent activity. Daraxonrasib (RMC-6236), ...

Utility of archived EUS-guided fine-needle biopsy samples for next-generation...

Mata(R),Alberti(P),García-Illescas(D),Agui... Endosc Ultrasound None

...KRAS mutations were identified in 73.1% of sequenced cases, predominantly at codon 12. EUS-guided FNB samples can suppor...

Mechanistic Insights Into Dose-Dependent Alleviation of Colorectal Cancer Thr...

Zahid(F),Ilyas(U),Zahid(S),Gulzar(F),Chinn... Dose Response None

...KRAS, IL-8, Caspase-8, PD-1 and PDL-1 in CRC, which were successfully treated with MSN-PEG@Artemisinin and standard Gemi...

Integrated transcriptomic analysis reveals KRAS-associated gene activation an...

Jeon(J),Park(J),Gim(S),Chung(C) Genes Genomics 2026-07-00

...KRAS-associated gene expression. We analyzed transcriptomic data from the TCGA-LGG cohort and public RNA-seq datasets to...

KRAS Mutations Predict Inferior Post-Remission Outcomes in Newly Diagnosed Ac...

Takaoka(K),Mott(S),Yodsuwan(R),Saowapa(S),... Eur J Haematol 2026-07-24

...KRAS mutation conferred an inferior effect on OS and RFS but not CRc. These findings suggest that KRAS mutations may con...

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