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Sianoya(AC),Zuo(Y),Pagba(CV),Jakubec(JL),P... Mol Cancer Ther 2026-03-14

...KRAS inhibition mechanisms. Here, we show that the KRAS (G12D)-selective MRTX1133 also binds to G12C mutant KRAS with hi...

Li(J),Wang(Z),Xia(Y),Li(Q),Yin(S),Mao(W),Y... Discov Oncol 2026-03-14

...KRAS mutations were 0.90 and 0.85, respectively, and the calibration curve confirmed that the predicted probability was ...

Xu(B),Chen(J),Peng(H),Su(X),He(C) J Pathol 2026-06-00

...KRAS, PRKDC, and CDKN1B, alongside frequent chromosome 12p amplifications in two cases. One particularly complex mediast...

Li(Z),Chen(X),Wu(Y),Xu(Y) Biochem Biophys Res Commun 2026-05-07

...KRAS inhibition induces compensatory activation of the CD59-JAK2-STAT3 axis, while combined targeting of CD59 or STAT3 w...

Lytan(I),Singha(B),Boruah(N),Gogoi(PP),Lon... Mini Rev Med Chem 2026-03-13

...KRAS G12C and immunotherapy targets have demonstrated reduced development time and improved selectivity. Overall, comput...

Li(J),Ni(Y),Huang(R),Zhang(Y),Wang(J),Hu(H... Cell Signal 2026-07-00

...KRAS. Mechanistically, KRAS binds to GLUT2, preventing its membrane translocation, reducing glucose uptake, thereby inhi...

Chhichholiya(Y),Singh(S),Vashistha(R),Rana... Front Genome Ed None

...KRAS. Luciferase assay confirmed that rs9266 disrupts the binding of hsa-let-7c and hsa-miR-181c, leading to increased K...

Xiang(Q),Mao(Z),Ma(Q),Su(M),Tang(D),Lan(S)... Onco Targets Ther None

...KRAS-mutant tumor cells and T cells through inhibiting TAK1/NF-κB axis. However, this regulatory effect was absent in KR...

Kabiri(Z),Zaribafzadeh(H),Raji(S),Carney(J... Front Cell Dev Biol None

...Kras-driven mouse models of lung adenocarcinoma, the loss of iNOS reduces tumorigenesis. To explore the additional loss ...

Sasaki(S),Sakaguchi(M),Takeda(M),Nitta(Y),... Brain Tumor Pathol 2026-03-15

...KRAS p.G12D mutation and polysomy of chromosome 1q and 19p, whereas the sarcomatous component harbored PTEN p.G165R and ...