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Yamada(Tadaaki),Amann(Joseph M),Fukuda(Koj... Cancer Res 2016-01-30

...PDK1-Akt signaling module that helps determine receptor signal selectivity for EGFR. Aki1 has been suggested as a therap...

Fang(Baojun),Zhu(Jianxin),Wang(Yunhua),Gen... Biomed Pharmacother 2016-11-08

...PDK1) as a target of miR-454 which acted as a tumor promoter gene. Increased miR-454 significantly repressed PDK1 expres...

Steiner(Jennifer L),Crowell(Kristen T),Kim... Am J Physiol Endocrinol Met... 2016-04-11

...PDK1, PP2A, or TSC2 expression. Sepsis increased autophagy as indicated by decreased ULK1 Ser(757) phosphorylation and p...

Kaler(Pawan),Godasi(Bramara N),Augenlicht(... Cancer Microenviron 2015-02-03

...PDK1 and AKT in tumor cells and thereby inhibit GSK3β activity. Consistently, dominant negative AKT (dnAKT), or pharmaco...

Yung(Hong Wa),Hemberger(Myriam),Watson(Eri... J Pathol 2015-01-05

...Pdk1-Akt-mTOR pathways was decreased in Eif2s1(tm1RjK) placentas, indicating loss of Igf2 signalling. Furthermore, we ob...

Li(Wan),Chen(Lina),Li(Xia),Jia(Xu),Feng(Ch... Mol Biosyst 2015-03-03

...PDK1 and AKT1 in the plasma membrane, to mediate signal transduction between 32 cancer-related pathways. Finally, we ana...

Pastor-Flores(Daniel),Schulze(Jörg O),Bahí... ACS Chem Biol 2015-02-26

...PDK1, is a master kinase that phosphorylates the activation loop of up to 23 AGC kinases. S. cerevisiae has three PDK1 o...

Chesnelong(Charles),Chaumeil(Myriam M),Blo... Neuro Oncol 2015-03-31

...PDK1, LDHA, SLC16A3), were underexpressed in IDH(mt) gliomas and/or derived BTSCs. We then demonstrated that LDHA was si...

Lin(Miao-chong J),Rojas(Katherine S),Cerio... Mol Cancer Res 2015-04-15

...PDK1(PDPK1)-dependent site (T308) as well as at the mTORC2-dependent site (S473). The elimination of Rictor (RICTOR), a ...

Hong(Hyun Ju),Kang(Wonyoung),Kim(Dong Geon... J Vet Sci 2015-02-05

...PDK1 (Ser241), GSK-3α (S21) and GSK-3 (Ser9), which are involved in the insulin signaling pathway, were decreased in the...