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Correlation between functional and molecular analysis of mdr1 P-glycoprotein in…

Broxterman(HJ),Feller(N),Kuiper(CM),Boven(E)… Int J Cancer 1995-06-09

...Pgp. In KB8-5 XG cells, Pgp function was hardly detectable, in accordance with decreased mdr1/Pgp expression in vivo. In...

Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.

Yasuda(Kazuto),Lan(Lu-Bin),Sanglard(Dominiqu… J Pharmacol Exp Ther 2002-10-21

...Pgp, compared with prototypical Pgp inhibitors. We used cell lines expressing human, mouse, and rat mdr1 genes. Pgp anta...

P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholest…

Connelly-Smith(Laura),Pattinson(Joanne),Grun… Exp Hematol 2008-02-01

...pgp) is a membrane transporter encoded by the multidrug resistance (MDR1, ABCB1) gene. Pgp is a poor prognostic factor i...

PGP 9.5, a new marker for human neuroendocrine tumours.

Rode(J),Dhillon(AP),Doran(JF),Jackson(P),Tho… Histopathology 1985-02-00

...PGP 9.5. In combination 63/74 of these tumours were positive for either NSE or PGP 9.5 or both. Staining for PGP 9.5 was...

Secondary structure of P-glycoprotein investigated by circular dichroism and am…

Dong(M),Ladavière(L),Penin(F),Deléage(G),Bag… Biochim Biophys Acta 1998-05-28

...Pgp from human, rat and murine Pgp-overexpressing drug resistant cells revealed slight variations in the spectral shape ...

MDR1 P-glycoprotein reduces influx of substrates without affecting membrane pot…

Luker(G D),Flagg(T P),Sha(Q),Luker(K E),Pica… J Biol Chem 2002-01-31

...Pgp; ABCB1) decreases intracellular concentrations of structurally diverse drugs. Although Pgp is generally thought to b...

Rapid induction of P-glycoprotein expression by high permeability compounds in …

Collett(Andrew),Tanianis-Hughes(Jolanta),War… Biochem Pharmacol 2004-09-08

...PGP had no effect on PGP expression. The induction of PGP by propranolol and verapamil was rapid with significant increa...

Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein an…

Ganguly(S),Panetta(JC),Roberts(JK),Schuetz(E… Drug Metab Dispos 2018-00-00

...Pgp KO > Bcrp KO > WT mice compared with WT mice. Inhibition of Bcrp and Pgp in WT mice using the dual Pgp/Bcrp inhibito...

The effects of anthracycline drugs on the conformational distribution of mouse …

Nguyen(PH),Sigdel(KP),Schaefer(KG),Mensah(GA… Biochem Pharmacol 2020-00-00

...Pgp tryptophan fluorescence to probe the tertiary structure of Pgp suggested that DNR shifts Pgp to a "closed" conformat...

[Functional activity of ABC transporters (markers of multidrug resistance) in h…

Bogush(E A),Ravcheeva(A B),Konukhova(A V),Bo… Antibiot Khimioter 2003-01-30

...Pgp and MRP functional activity was determined in about 50% and 70% of colon tumors respectively. Pgp+MRP+ phenotype was...

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