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Transcriptional regulators in the Hippo signaling pathway control organ growth …

Hayashi(S),Ochi(H),Ogino(H),Kawasumi(A),Kame… Dev Biol 2014-12-01

...Tead4 (dnTead4) under a heat-shock promoter in transgenic animal lines. Each inhibition resulted in regeneration defects...

YAP transcriptionally regulates ErbB2 to promote liver cell proliferation.

Wang(EY),Cheng(JC),Thakur(A),Yi(Y),Tsai(SH),… Biochim Biophys Acta Gene Reg… 2018-07-17

...TEAD4 at the ERBB2 promoter. Using luciferase reporter and chromatin immunoprecipitation assays, we show that YAP and TE...

YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prog…

Xia(Y),Chang(T),Wang(Y),Liu(Y),Li(W),Li(M),F… PLoS One 2014-00-00

...TEAD4 gene expression, and their co-expression was a prognostic marker for poor ovarian cancer survival. Hyperactivation...

Discovery and optimization of novel TEAD inhibitors for in vivo investigation a…

Xu(D),Su(W),Miao(Y),Luo(X),Luo(Y),Hu(S),Wang… Eur J Med Chem 2026-09-05

...TEAD4, but reduced potency against TEAD3. LC-TD-05 exhibits good potency against TEAD1/2/4 (TEAD1 IC50 = 116.6 ± 21.7 nM...

Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angi…

Fan(M),Yang(K),Wang(X),Wang(Y),Tu(F),Ha(T),L… JCI Insight 2020-00-17

...TEAD4) and a coactivator in YAP-associated angiogenesis. In vivo studies using the MI model showed that endothelial cell...

Bulk and single-cell transcriptome profiling reveal extracellular matrix mechan…

Cai(J),Chen(T),Jiang(Z),Yan(J),Ye(Z),Ruan(Y)… Int J Biol Sci 2023-00-00

...TEAD4) transcriptional complex was able to directly repress ACADL at the transcriptional level. The ACADL-dependent mech...

Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistic…

Watanabe(Y),Miyasaka(KY),Kubo(A),Kida(YS),Na… Sci Rep 2017-00-12

...Tead4 reside normally in nuclei. Accordingly, Sbno1 acts on the trophectoderm-enhancer (TEE) of Cdx2, ensuring its robus...

LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedb…

Liu(S),Li(H),Zhu(Y),Ma(X),Shao(Z),Yang(Z),Ca… Cancer Lett 2022-00-28

...TEAD4), and suppresses insulin-like growing factor 2 mRNA-binding protein 3 (IGF2BP3) degradation by recruiting ubiquiti...

Identification and Characterization of Copy Number-Associated Driver Genes in E…

Jiang(K),He(Y),Zhang(X) Biomed Res Int 2020-00-00

...TEAD4, EIF4EBP1, EGFR, FGFR3, and FZD6. Furthermore, we identified oncogenic pathways, including RTK-RAS, WNT, PI3K, Hip...

Employing Broad Substrate Specificity of Omniligase to Generate Phage-Encoded B…

Wan(XC),Zhu(WJ),Wei(HM),Zhang(YN),Zheng(FH),… Org Lett 2025-05-02

...TEAD4 with a KD value of 1.5 μM, 100-fold lower than its linear version, demonstrating the utility of this platform for ...

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