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Dual targeting of IGF-1R and K-RAS with natural phytochemicals for lung cance...

Ahmed(SF),Hossen(Z),Chakraborty(I),Rahman ... J Genet Eng Biotechnol 2026-03-00

...KRAS). A library of 1584 phytochemicals derived from 12 medicinal plants was retrieved from the IMPPAT 2.0 database and ...

Tumor-intrinsic metabolic pathways essential for tumorigenesis and resistance...

Vasan(K),Chalmers(ZR),Kong(H),Chandel(NS) Cancer Metab 2026-03-16

...Kras and p53 loss-driven murine lung adenocarcinoma cell line. The IgG control arm revealed essential metabolic dependen...

Triple-Synergistic Therapy with Cobalt-Pheophytin Coordination Micelles for O...

Jiang(Z),Pan(Y),Liu(G),Ren(H),Zhang(Y) ACS Appl Bio Mater 2026-04-06

Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies as KRAS (Kirsten rat sarcoma viral ...

E2A selectively regulates TGF-β-induced apoptosis in KRAS-mutant non-small ce...

Chuikov(S),Katkam(SK),Wang(Z),Keshamouni(V... Mol Oncol 2026-07-00

...KRAS, but not in those with wild-type KRAS. Silencing E2A restores TGF-β-induced apoptosis in mutant KRAS cell lines wit...

Colorectal Micropapillary Adenocarcinoma: Molecular Mechanisms and Clinical I...

Chen(B),Zhang(R),Ding(Y),Zhang(K),Song(X),... J Gastrointest Cancer 2026-03-17

...KRAS, BRAF, and TP53 enhance tumor invasiveness by modulating signaling pathways and promoting epithelial-mesenchymal tr...

Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mous...

Zhang(Z),Fan(C),Jorgensen(R),Sylvestre(P),... Nat Commun 2026-03-18

...Kras expression in mice causes small intestine failure leading to weight loss, inflammation, epithelial necroptosis, and...

BKDRP: a biological knowledge-driven approach for drug response prediction us...

Mandal(K),Bandyopadhyay(S) BMC Bioinformatics 2026-03-17

...KRAS, EGFR, STK11), key proteins (SOCS1, HSPA8, SMC3), and drugs (Erlotinib, Palbociclib) that are consistent with the l...

Toward precision chemotherapy in pancreatic ductal adenocarcinoma: molecular,...

Capurso(G),Garajova(I),Neuzillet(C),Leta(L... Dig Liver Dis 2026-05-00

...KRAS-targeted therapies may extend molecularly guided treatment to a broader population. Beyond genomics, emerging bioma...

Sintilimab plus anlotinib in later-line treatment of advanced KRAS-mutant NSC...

Su(Y),Wang(C),Sun(L),Jin(F),Wang(X),Wang(S... Front Med (Lausanne) None

Patients with advanced KRAS-mutant non-small cell lung cancer (NSCLC) face a paucity of effective later-line therapies. ...

Engineered subtilisin protease degrades active KRAS in cancer cells, leading ...

Goldstein(ME),Chu(B),Carillo(KJ),Orban(J),... bioRxiv 2026-03-06

...KRAS G12C and is KRAS-dependent for growth and survival. We found that cleavage of KRAS G12C coincided with a decrease i...

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