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Misra(Uma Kant),Pizzo(Salvatore Vincent) PLoS One 2015-01-13

...PDK1, Raptor, and mTOR co-immunoprecipitate. Silencing the expression, not only of PDK1, but also Raptor by RNAi nearly ...

Yang(Meixiang),Li(Dan),Chang(Zai),Yang(Zho... J Exp Med 2015-04-23

...PDK1, a kinase upstream of mTOR, connects IL-15 signaling to E4BP4. Early deletion of PDK1 caused a severe loss of NK ce...

Tatsumi(Y),Takano(R),Islam(M S),Yokochi(T)... Cell Death Dis 2015-09-11

...PDK1. BMCC1 upregulation was correlated with the activation of forkhead box-O3a (FOXO3a) (a downstream inducer of apopto...

Verma(Rita),Marchese(Adriano) J Biol Chem 2015-05-29

...PDK1) pathway. However, the molecular mechanisms by which GPCRs govern Akt activation by these kinases remain poorly und...

Bruserud(Øystein),Reikvam(Håkon),Fredly(Ha... Oncotarget 2015-12-03

...PDK1, SRC, STAT1, p38, STAT3, rpS6) that are important for PI3K-Akt-mTOR signaling and/or transcriptional regulation. Hi...

O'Neill(C),Li(Y),Jin(X L) Adv Exp Med Biol 2015-10-09

...PDK1, AKT and phospholipase C. The activation of these proteins accounts for the initiation of new transcription from th...

Reyer(Anja),Schindler(Nancy),Ohde(Daniela)... Am J Physiol Endocrinol Met... 2015-11-17

...PDK1/Akt activation in both models, we have identified increased levels of integrin-linked kinase and focal adhesion kin...

Jeoung(Nam Ho) Diabetes Metab J 2015-06-30

...PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2). PDKs and PDPs exhibit unique tissue expression patterns...

Han(Zhonglin),Jiang(Yu),Yang(Zhongzhou),Ca... Int J Clin Exp Med 2015-07-01

...PDK1(F/F) αMHC-Cre mice and PDK1(F/F) mice were divided into experiment group and control group. Using patch clamping te...

Sanders(Edward),Diehl(Svenja) Oncoscience 2015-04-10

...PDK1, and SLC16A1. Genes that are highly under-expressed include ALDOB, PKLR, PFKFB2, G6PC, PCK1, FBP1, PC, and SUCLG1.