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The effects of anthracycline drugs on the conformational distribution of mouse …

Nguyen(PH),Sigdel(KP),Schaefer(KG),Mensah(GA… Biochem Pharmacol 2020-00-00

...Pgp tryptophan fluorescence to probe the tertiary structure of Pgp suggested that DNR shifts Pgp to a "closed" conformat...

Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3…

Guo(WY),Li(RR),Fu(YX),Liu(SY),Liu(GZ),Yang(W… Anal Chem 2021-00-05

...PGP-I), a common exopeptidase, was recently identified as a novel inflammatory cytokine in cells. However, whether PGP-I...

Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acet…

Tang(W),Yi(C),Kalitsky(J),Piquette-Miller(M) Mol Cell Biol Res Commun 2000-08-00

...PGP and MRP2. Thus, we examined the influence of endotoxin on the expression of PGP and MRP2 in AAF-treated rats. Expres...

P-glycoprotein--a clinical target in drug-refractory epilepsy?

Robey(Robert W),Lazarowski(Alberto),Bates(Su… Mol Pharmacol 2008-05-06

...Pgp in epilepsy in humans as well. However, few epilepsy drugs have been shown to be transported by Pgp, leading to cont...

Allosteric modulation of the human P-glycoprotein involves conformational chang…

Ghosh(Pratiti),Moitra(Karobi),Maki(Nazli),De… Arch Biochem Biophys 2006-07-11

...Pgp modulators with an allosteric mode of action induce a distinct conformational change in the cytosolic domain of Pgp,...

P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtub…

van der Sandt(I C),Gaillard(P J),Voorwinden(… Pharm Res 2001-12-05

...Pgp by various Pgp modulators and substrates, even low concentrations of vinblastine, colchicine and paclitaxel substant...

Role of P-glycoprotein in drug disposition.

Tanigawara(Y) Ther Drug Monit 2000-02-00

...Pgp, which regulates the renal tubular secretion and brain distribution of digoxin. At present, potent Pgp inhibitors ar...

P-glycoprotein expression in mouse brain increases with maturation.

Tsai(Catherine E),Daood(Monica J),Lane(Rober… Biol Neonate 2002-03-15

...Pgp mRNA and protein was indexed as a percent (mean +/- SEM) of D0 levels. Pgp mRNA levels increased significantly (p < ...

Indole-3-acetic acid (IAA) production trait, a useful screening to select endop…

Etesami(Hassan),Alikhani(Hossein Ali),Hossei… MethodsX 2015-07-07

...PGP agents based on a root colonization bioassay and a PGP trait is characterized. •Selected bacterial isolates based on...

Insights into interactions between taxanes and P-glycoprotein using biophysical…

Xu(L),Schaefer(KG),King(GM),Xie(ZR),Bartlett… J Pharm Sci 2025-05-00

...Pgp substrates, but cabazitaxel is also a Pgp inhibitor, indicating potential differential interactions between Pgp and ...

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