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Modeling mechanisms of in vivo variability in methotrexate accumulation and fol…

Panetta(John C),Sparreboom(Alex),Pui(Ching-H… PLoS Comput Biol 2011-03-31

...PBX1) subtype (p<0.03) than other genetic subtypes. In addition, the folate pathway model showed differential inhibition...

Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by …

Chang(Ming-Jin),Wu(Hongyu),Achille(Nicholas … Cancer Res 2011-01-20

...Pbx1. Although this effect is most pronounced for MLL-AF9, we find that Dot1 contributes to the viability of cells immor...

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell surviva…

Liu(Jiangying),Wang(You),Birnbaum(Morris J),… Proc Natl Acad Sci U S A 2011-01-20

...Pbx1 regulates the development and function of insulin-producing pancreatic β-cells, the role of Meis family members in ...

Concerted dynamics link allosteric sites in the PBX homeodomain.

Farber(Patrick J),Mittermaier(Anthony) J Mol Biol 2011-02-07

...PBX1 homeodomain (PBX-HD) cooperatively binds DNA with Hox transcription factors and helps to regulate gene expression d...

A case of adult B lymphoblastic leukemia with ider(9)(q10)t(9;22)(q34;q11.2) an…

Jung(Soon Il),Cho(Hee Soon),Lee(Chae Hoon),J… Korean J Lab Med 2011-04-28

...PBX1; however, a few cases have identical translocations but no TCF3-PBX1 fusion, as was observed in our patient. We des...

The role of meis1 in primitive and definitive hematopoiesis during zebrafish de…

Cvejic(Ana),Serbanovic-Canic(Jovana),Stemple… Haematologica 2011-09-27

The Meis1 protein represents an important cofactor for Hox and Pbx1 and is implicated in human and murine leukemias. Tho...

Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem a…

Oshima(Motohiko),Endoh(Mitsuhiro),Endo(Takah… Blood 2011-06-21

...Pbx1, Nov, AhR, and Hemgn. HoxB4 tended to activate the transcription, but the down-regulation of a significant portion ...

Analysis of PBX1 mutations in 192 Chinese women with Müllerian duct abnormaliti…

Ma(Jinlong),Qin(Yingying),Liu(Wen),Duan(Hua)… Fertil Steril 2011-08-26

We examined the PBX1 gene in 192 Chinese women with Müllerian duct abnormalities and revealed 2 known single nucleotide ...

[Correlation of E2a-pbx1 expression level with clinical characteristics and ear…

Gao(Chao),Li(Zhi-Gang),Zhao(Wei),Wu(Min-Yuan) Zhongguo Shi Yan Xue Ye Xue Z… 2010-01-12

...pbx1 at primary diagnosis and the clinical characteristics. The expression level of e2a-pbx1 at primary diagnosis in MRD...

[Classical and molecular cytogenetic abnormalities in 124 pediatric patients wi…

Chai(Yi-huan),Lü(Hui),Li(Jian-qin),Lu(Jun),X… Zhonghua Er Ke Za Zhi 2010-12-22

...PBX1, 4 cases of E2A-HLF, 3 cases of BCR-ABL, 2 cases of TLS-ERG, 32 cases of HOX11 were detected by Multiplex PCR in B-...

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