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Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat,...

Ogino(Tomoe),Moralejo(Daniel H),Kose(Hiroy... Mamm Genome 2004-07-20

...GCKR) for Olep2.

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and...

Shi(Chong-Shan),Kehrl(John H) J Biol Chem 2003-07-16

...GCKR, the RING finger domain is needed for their activation. Here, we report that TNF activates GCKR and the SAPK pathwa...

MAP kinase activation in macrophages.

Rao(K M) J Leukoc Biol 2001-03-22

...GCKR). Although, these pathways have been described in various cell types, their role in macrophages remains to be estab...

TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-...

Chin(A I),Shu(J),Shan Shi(C),Yao(Z),Kehrl(... Mol Cell Biol 2000-02-03

...GCKR). However, when coexpressed, they formed a strong complex with GCKR, thereby providing a potential mechanism for TR...

Adaptor proteins CRK and CRKL associate with the serine/threonine protein kin...

Shi(C S),Tuscano(J),Kehrl(J H) Blood 2000-02-24

...GCKR, each coimmunoprecipitated with GCKR. Furthermore, in the Bcr-Abl transformed cell line, K562 endogenous GCKR and C...

TNF-mediated activation of the stress-activated protein kinase pathway: TNF r...

Shi(C S),Leonardi(A),Kyriakis(J),Siebenlis... J Immunol 1999-10-04

...GCKR, also referred to as KHS1), which signals activation of the SAPK pathway. Consistent with a role for GCKR in TNF- i...

GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinas...

Shi(C S),Tuscano(J M),Witte(O N),Kehrl(J H... Blood 1999-03-11

...GCKR activation are also unable to activate SAPK. Consistent with GCKR being a functional target in CML, GCKR is constit...

Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but no...

Shi(C S),Kehrl(J H) J Biol Chem 1998-01-22

...GCKR activity. A TRAF2 mutant, which inhibits both TRAF2-induced NF-kappaB and SAPK activation, blocked TNF-induced GCKR...

Organization of the human glucokinase regulator gene GCKR.

Hayward(B E),Dunlop(N),Intody(S),Leek(J P)... Genomics 1998-06-25

...GCKR). GCKR has therefore become an important gene for functional analysis in type 2 diabetes. To allow genetic assessme...

Genetics of NIDDM in France: studies with 19 candidate genes in affected sib ...

Vionnet(N),Hani(E H),Lesage(S),Philippi(A)... Diabetes 1997-06-19

...GCKR), glucagon-like peptide I receptor (GLP1R), LIM/homeodomain islet-1 (ISL1), caudal-type homeodomain 3 (CDX3), propr...

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