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Bertacchini(Jessika),Heidari(Nazanin),Medi... Cell Mol Life Sci 2015-07-30

...PDK1 inhibitor in CML, AML, APL, CLL, B-ALL and T-ALL has a better therapeutic effect than conventional treatments.,Targ...

Yan(Ribai),Chuang(Hsiao-Ching),Kapuriya(Na... J Med Chem 2015-06-15

...PDK1, were an order-of-magnitude lower. Moreover, 20 was orally active in suppressing xenograft tumor growth in nude mic...

Jin(Zhong-Tian),Li(Kun),Li(Mei),Ren(Zhi-Ga... Chin Med J (Engl) 2015-09-28

...PDK1 (P < 0.01), phosphorylation of PDK1 (P < 0.01), Akt (P < 0.01), and ERK (P < 0.01). Furthermore, GPR34 knockdown re...

Sturm(Eva M),Parzmair(Gerald P),Radnai(Bal... Eur J Immunol 2015-08-03

...PDK1 seemed to act through PI3K-dependent or PI3K-independent mechanisms. Stimulation of EP4 receptors caused PDK1 phosp...

Nakayama(Masaaki),Inoue(Tetsuyoshi),Naito(... J Biol Chem 2015-05-06

...PDK1 translocation to the plasma membrane was reduced by wild-type P. gingivalis, but not KDP136, indicating little prod...

Liu(Xiao-Liang),Liu(Huan-Qiu),Li(Ji),Yang(... Zhongguo Zhong Xi Yi Jie He... 2015-05-16

...PDK1 was verified by using Western blot.,Compared with the control group, the inhibition rate on CAL-27 increased signif...

Tsang(Stephen H),Chan(Lawrence),Tsai(Yi-Ti... Trans Am Ophthalmol Soc 2015-08-03

...PDK1), ribosomal protein S6 (RPS6), and tuberin. Tuberin gene silencing rescued photoreceptors from degeneration.,Phosph...

Xie(Qi),Zhang(Han-Fang),Guo(Ying-Zi),Wang(... Mol Med Rep 2015-09-28

...PDK1 protein and mRNA expression. Elevated PDK1 levels contribute to Taxol resistance under hypoxic conditions. Inhibiti...

Rettenmaier(T Justin),Sadowsky(Jack D),Tho... Proc Natl Acad Sci U S A 2015-04-22

...PDK1 called the PDK1-interacting fragment (PIF)tide-binding site, or PIF pocket. More than two dozen prosurvival and pro...

Datta(Sanchita),Roy(Syamal),Manna(Madhumit... Braz J Infect Dis 2015-08-26

...PDK1), phosphoinositide 3 kinase (PI3K) and p38 mitogen activated protein kinase (p38MAPK) molecules were checked in BAL...