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Skolnick(J),Srinivasan(B),Zhou(H) J Chem Inf Model 2026-03-23

...KRAS, and predicted candidate glues that recruit 24, 111, and 148 distinct E3 ligases to these targets, respectively. We...

Tang(C),Wang(T),Liu(Y),Chang(P),Li(Y),Xion... Medicine (Baltimore) 2026-05-15

...KRAS) mutations were included. Multi-layer perceptron (MLP) models were developed for each genetic mutation group based ...

Kühl(L),Löffler(AK),Seifert(O),Michler(D),... MAbs 2026-12-00

...KRAS. However, intrinsic and acquired resistance to EGFR-targeted antibody therapies such as cetuximab remains a major l...

Molavand(M),Valizadeh(A),Yousefi(B) Curr Mol Med 2026-05-12

...KRAS and BRAF mutant variants. Various facets of CRC advancement are intricately related to ERK hyperactivity. Prominent...

Liu(J),Li(J),Fu(R),Fang(L),Liu(Y),Liu(R),K... Epilepsy Res 2026-08-00

...Kras, Raf-1, Mek, Erk) using western blot (WB) and quantitative real-time polymerase chain reaction (qRT-PCR). Both PTZ ...

Srinivasalu(VK),Subramaniam(N),Ibrahim(M),... J Gastroenterol Hepatol 2026-07-00

...KRAS/NRAS, BRAF, and MSI status, while foundational, are insufficient to address the full complexity of CRC biology. Ove...

Vincent(M),Tiriau(S),Fouillet-Desjonqueres... Commun Med (Lond) 2026-05-18

...KRAS function, we conducted transient KRAS overexpression in HEK293 cells and then tested the effect of the MEK-inhibito...

Chen(WY),Chen(WC),Tan(PH),Chen(YM),Chuang(... Virchows Arch 2026-05-19

...KRAS and TERT alterations were each identified in one case. The expanded targeted sequencing results further revealed ad...

Vitale(D),Colarossi(L),Russo(G),Scimone(C)... Pathologica 2026-04-00

...KRAS, NRAS, BRAF, cKIT, PDGFRα) relevant to targeted therapies in several solid tumors. We implemented a multiplexed ass...

Song(R),Liang(SH) ACS Med Chem Lett 2026-05-14

...KRAS) G12C, which is extensively expressed across a variety of cancers. The patent provides detailed description of the ...