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Konno(Masamitsu),Doki(Yuichiro),Mori(Masak... Nihon Rinsho 2015-08-06

...PDK1 expression by controlling its transcription. PKM2 confers malignant potential by controlling both metabolism and tr...

Ong(Sang-Ging),Lee(Won Hee),Theodorou(Loui... Cardiovasc Res 2015-06-10

...PDK1) and hexokinase II (HKII), and reprogrammed cell metabolism to aerobic glycolysis, thereby resulting in the product...

Setia(Shruti),Nehru(Bimla),Sanyal(Sankar N... Biomed Pharmacother 2015-06-22

...PDK1, mTOR, GSK-3β, Wnt and β-catenin and found the elevated levels of these proteins, except the tumor suppressors PTEN...

Ko(Young Bok),Kim(Boh-Ram),Yoon(Kyungsil),... Cell Signal 2015-05-15

...PDK1, mTOR, TSC-2, GSK-3β, and the p70S6K protein. Collectively, our results indicate for the first time that the tumor ...

Ohtsubo(Koushiro),Yamada(Tadaaki),Zhao(Lu)... Pancreas 2015-05-25

...PDK1 (3-phosphoinositide-dependent protein kinase)/Akt pathway and to interact with epidermal growth factor receptor sig...

Han(Lihong),Zhang(Guoxiu),Zhang(Nali),Li(H... Med Oncol 2015-04-02

...PDK1 expression (P = 0.01), and combined expression of miR-138 and PDK1 (miR-138/PDK1, P = 0.001) were all independent p...

Silva(Andres),Wang(Jennie),Lomahan(Sarah),... Oncol Rep 2015-11-03

OSU-03012, a 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitor, destabilizes MYCN and MYC proteins in neuroblastoma...

Alcántara-Hernández(Rocío),Hernández-Ménde... Eur J Pharmacol 2015-10-27

...PDK1 construct. Other PDK1 inhibitors were also tested: OSU-03012 induced a clear decrease in phospho-PDK1 and increased...

Hwang(Joo-Yeon),Sim(Xueling),Wu(Ying),Lian... Diabetes 2015-03-11

...PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fa...

Zhang(Yingchi),Hu(Tianyuan),Hua(Chunlan),G... PLoS One 2015-11-16

...PDK1 and at Ser473 by mTORC2, and Akt signaling plays a key role in hematopoiesis. However, the role of mTORC2 in the de...