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The mechanism of the neurotransmitter release in growth cones.

Igarashi(M),Ohyama(A),Ohbayashi(K),Kozaki(... J Neurosci Res 2000-09-06

...rab3A cycling was blocked. By supplying rabphilin, a rab3A acceptor found in low levels in IGC, the IGC obtained as high...

Genomic organization, chromosomal localization, and expression of the murine ...

Adachi(R),Nigam(R),Tuvim(M J),DeMayo(F),Di... Biochem Biophys Res Commun 2000-09-08

...rab3A but different from other rab genes. Alternative poly-A(+) signals in the 3' untranslated region account for the id...

Biochemical characterization of Rab3-GTPase-activating protein reveals a mech...

Clabecq(A),Henry(J P),Darchen(F) J Biol Chem 2000-11-13

...Rab3A in solution. The K(m) and K(d) values (75 microm) indicate a low affinity of Rab3-GAP for its substrate. The affin...

Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheim...

Sze(C I),Bi(H),Kleinschmidt-DeMasters(B K)... J Neurol Sci 2000-08-11

...Rab3a (30%, P<0.05) in hippocampus; synaptobrevin (31%, P<0.01), synaptotagmin (15%, P<0.05), and Rab3a (44%, P<0.05) in...

The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and i...

Iezzi(M),Regazzi(R),Wollheim(C B) FEBS Lett 2000-07-06

...Rab3A reversed the effect of RIM on exocytosis. These results suggest an implication of RIM in the control of insulin se...

Prion protein deposition and abnormal synaptic protein expression in the cere...

Ferrer(I),Puig(B),Blanco(R),Martí(E) Neuroscience 2000-07-24

...Rab3a accumulated in the cytoplasm of Purkinje cells, thus suggesting major anomalies in Rab3a transport. These observat...

A rab3 homolog in sea urchin functions in cell division.

Conner(S D),Wessel(G M) FASEB J 2000-08-25

...rab3A-D), a single family member homologue of rab3 is present in the rapidly dividing cleavage stage sea urchin embryo t...

Piccolo, a presynaptic zinc finger protein structurally related to bassoon.

Fenster(S D),Chung(W J),Zhai(R),Cases-Lang... Neuron 2000-03-23

...rab3A and VAMP2/Synaptobrevin II receptor PRA1. We show that PRA1 is a synaptic vesicle-associated protein that is coloc...

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C...

Sullivan(M),Olsen(A S),Houslay(M D) Cell Signal 2000-01-31

...RAB3A. The RAB3A gene was shown to consist of 5 exons spanning 7.9 kb, while the JUND gene was found to contain no intro...

High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiatio...

Joberty(G),Stabila(P F),Coppola(T),Macara(... J Cell Sci 2000-01-10

...Rab3A on the secretory vesicle membrane. The Rab3 binding domain (residues 45 to 170), located in the N-terminal part of...

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