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[Effects of astaxanthin on renal fibrosis and cell apoptosis induced by parti...

Xie(Chaoxin),Meng(Meng),Yin(Xianfeng),He(F... Nan Fang Yi Ke Da Xue Xue B... 2013-12-30

...SGK1, and CTGF in the left kidney were detected immunohistochemically; the expression level of Bcl-2 and Bax were detect...

Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.

Ko(Benjamin),Mistry(Abinash C),Hanson(Laur... Am J Physiol Renal Physiol 2013-11-26

...SGK1). Furthermore, STE20/SPS-1-related proline/alanine-rich kinase (SPAK) phosphorylation also increased, and gene sile...

WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mi...

Yue(Peng),Zhang(Chengbiao),Lin(Dao-Hong),S... Biochim Biophys Acta 2013-09-26

...SGK1 had no additional effect on K currents in the cells transfected with BKα+WNK4(S1169D//1196D), suggesting that SGK1 ...

Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on...

Anacker(Christoph),Cattaneo(Annamaria),Mus... Proc Natl Acad Sci U S A 2013-08-06

...SGK1-dependent. SGK1 also potentiated and maintained GR activation in the presence of cortisol, and even after cortisol ...

The RNA degradation pathway regulates the function of GAS5 a non-coding RNA i...

Tani(Hidenori),Torimura(Masaki),Akimitsu(N... PLoS One 2013-07-17

...SGK1, were down-regulated. In addition, serum starvation also increased the transcript levels of GAS5 because of prolong...

Therapeutic potential of serum and glucocorticoid inducible kinase inhibition...

Lang(Florian),Voelkl(Jakob) Expert Opin Investig Drugs 2013-12-17

...SGK1 knockout mice is mild and SGK1 is apparently dispensible for basic functions. Excessive SGK1 expression and activit...

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects si...

Thomanetz(Venus),Angliker(Nico),Cloëtta(Di... J Cell Biol 2013-06-11

...SGK1 without effects on mTORC1 activity. The striking decrease in the activation and expression of several PKC isoforms,...

Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced...

Tao(Guo-Zhong),Lehwald(Nadja),Jang(Kyu Yun... J Biol Chem 2013-08-21

...SGK1, a β-catenin target gene, was significantly impaired in β-catenin KD hepatocytes that failed to inactivate FoxO3. F...

The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG c...

Lamothe(Shawn M),Zhang(Shetuan) J Biol Chem 2013-08-05

...SGK1 and SGK3 increased the current and expression level of the membrane-localized mature proteins of hERG channels stab...

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

Sommer(Eeva M),Dry(Hannah),Cross(Darren),G... Biochem J 2013-08-06

...SGK1 that also exhibited significant phosphorylation of the SGK1 substrate NDRG1 [N-Myc (neuroblastoma-derived Myc) down...

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