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Autoantibodies against protein disulfide isomerase ER-60 are a diagnostic mar...

Fijak(Monika),Zeller(Thomas),Huys(Tatjana)... Hum Reprod 2015-06-22

...CCT5) were considered as specific. Since ER-60 reacted with 92% of patient sera, an ER-60-autoantibody ELISA was develop...

Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes p...

Nishida(Yoriko),Aida(Kaoru),Kihara(Makoto)... PLoS One 2015-06-22

...CCT5), the anti-oxidative enzyme 6-phosphogluconate dehydrogenase (PDG), and the anti-viral and anti-apoptotic proteins ...

A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer asse...

Min(Wonki),Angileri(Francesca),Luo(Haibin)... Sci Rep 2015-11-09

...CCT5, causes neuropathy. Knowledge is scarce on the impact of this and other mutations upon the chaperone's structure an...

Hereditary spastic paraplegia: clinico-pathologic features and emerging molec...

Fink(John K) Acta Neuropathol 2014-04-07

...CcT5 mutation and presumably SPG18/ERLIN2); (6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesi...

Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 ...

Sergeeva(Oksana A),Tran(Meme T),Haase-Pett... J Biol Chem 2014-12-17

...CCT5, and WT CCT5 revealed similar ring structures. CCT5 complexes were assayed for their ability to suppress aggregatio...

Genome-wide association study meta-analysis of chronic widespread pain: evide...

Peters(Marjolein J),Broer(Linda),Willemen(... Ann Rheum Dis 2013-04-17

...CCT5) and downstream of FAM173B, was found to be associated with a 30% higher risk of CWP (minor allele frequency=43%; O...

Genetic association with overall survival of taxane-treated lung cancer patie...

Niu(Nifang),Schaid(Daniel J),Abo(Ryan P),K... BMC Cancer 2013-06-28

...CCT5, CMBL, EXO1, KMO and OPN3, genes within 200 kb up-/downstream of the 3 SNPs that were associated with SCLC overall ...

Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form bi...

Sergeeva(Oksana A),Chen(Bo),Haase-Pettinge... J Biol Chem 2013-08-21

...CCT5, but not the other six CCT subunits, formed high molecular weight complexes within the E. coli cells that sedimente...

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic ...

Dekker(Carien),Roe(S Mark),McCormack(Eliza... EMBO J 2011-10-03

...Cct5 on the outside of the barrel, confirmed by mutational studies, is unique to eukaryotic cytosolic chaperonins.

Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome v...

Inoue(Yasushi),Aizaki(Hideki),Hara(Hiromic... Virology 2011-02-17

...CCT5 and the viral RNA polymerase NS5B. siRNA-mediated knockdown of CCT5 suppressed RNA replication and production of th...

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