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DOC2b is a SNARE regulator of glucose-stimulated delayed insulin secretion.

Miyazaki(Mutsuko),Emoto(Masahiro),Fukuda(N... Biochem Biophys Res Commun 2009-06-19

...DOC2b translocation were suitable for the regulation of second-phase insulin release. Increased DOC2b expression enhance...

DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 v...

Fukuda(Naofumi),Emoto(Masahiro),Nakamori(Y... Diabetes 2009-03-31

...DOC2b constructs or silencing DOC2b.,Herein, we show that DOC2b, a SNARE-related protein containing double C2 domains bu...

DOC2B acts as a calcium switch and enhances vesicle fusion.

Friedrich(Reut),Groffen(Alexander J),Conne... J Neurosci 2008-08-12

...DOC2B and a mutated DOC2B that is constantly at the PM showed that DOC2B enhances catecholamine secretion also during re...

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-depende...

Groffen(Alexander J A),Friedrich(Reut),Bri... J Neurochem 2006-06-22

...DOC2B are modulated by submicromolar calcium levels. Fluorescent-tagged DOC2A and DOC2B translocated to plasma membranes...

Calcium concentration threshold and translocation kinetics of EGFP-DOC2B expr...

Malkinson(Guy),Spira(Micha E) Cell Calcium 2006-03-21

...DOC2B to Munc13, suggested that DOC2B could play a role in augmentation and potentiation of synaptic release. Neverthele...

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the targ...

Groffen(Alexander J A),Brian(Elisabeth C),... J Biol Chem 2004-07-29

...DOC2B to the target membrane. This novel mechanism occurred readily in the absence of Munc13 and was not influenced by D...

Different spatiotemporal expression of DOC2 genes in the developing rat brain...

Korteweg(N),Denekamp(F A),Verhage(M),Burba... Eur J Neurosci 2000-03-16

DOC2A and DOC2B are two homologous genes implicated in synaptic vesicle exocytosis. Their complementary, nonoverlapping ...

DOC2 proteins in rat brain: complementary distribution and proposed function ...

Verhage(M),de Vries(K J),Røshol(H),Burbach... Neuron 1997-04-24

...DOC2B ubiquitous. Within brain, the isoforms were expressed nonuniformly and complementary within neurons, not astroglia...

Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from pla...

Toft-Bertelsen(Trine Lisberg),Ziomkiewicz(... Mol Biol Cell 0000-00-00

...Doc2B or ubMunc13-2 increases syntaxin-1 immunoavailability and concomitantly down-regulates Ca currents. Similar findin...

Ring-like oligomers of Synaptotagmins and related C2 domain proteins.

Zanetti(Maria N),Bello(Oscar D),Wang(Jing)... Elife 0000-00-00

...Doc2B and extended Synaptotagmins (E-Syts). Evidently, circular oligomerization is a general and conserved structural as...

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