Xu(Y),Shi(S),Tan(B),Li(X),Leng(X) Animals (Basel) 2026-09-03

...hexb, hacd) and immune/antioxidant genes (ddo, xdh, npc2, galst, gst3) were upregulated by dietary RA. In summary, dieta...

Taghian(T),Gallagher(J),Bertrand(S),Baker(... J Clin Invest 2025-12-01

...HexB) encoding both HEXA and HEXB in the TSD sheep model. Bidirectional AAV9 was delivered i.v. or through various cereb...

Peihui(Z),Jianing(C),Chuwen(L),Hanjin(R),W... Int Immunopharmacol 2025-09-23

...Hexb+, tumor necrosis factor-α + (TNF-α+), Retnig+, Cxcl10, and CD74 neutrophils. Among these, the proportion of TNF-α +...

Duffy(HBD),Byrnes(C),Zhu(H),Lee(YT),Olmste... Neurobiol Dis 2025-10-15

...Hexb, genes linked to Tay-Sachs and Sandhoff disease, respectively. This model reveals that pathogenic α-syn amplifies G...

Frosch(M),Shimizu(T),Wogram(E),Amann(L),Gr... Nature 2025-10-00

...Hexb, encoding the β subunit of β-hexosaminidase, in both mice and patients with neurodegenerative Sandhoff disease lead...

Wang(J),Li(H),Shi(M),Ren(C),Wei(W),Zhao(Q)... Front Immunol 2025-00-00

...HEXB, IL10) were identified through integrative analysis, which formed the basis of a robust risk stratification model. ...

Eichler(F),Cataltepe(OI),Daci(R),Puri(AS),... Nat Med 2025-09-00

...HEXB vector can restore central nervous system hexosaminidase (Hex) enzyme activity, decrease GM2 levels in cerebrospina...

Daci(R),Shazeeb(MS),Owusu-Adjei(B),Kühn(A)... J Neurosurg Pediatr 2025-11-01

...HEXB delivery via CED for GM2 gangliosidoses. The approximate trajectory entered the middle frontal gyrus, lateral to th...

Udayantha(HMV),Bathige(SDNK),Kim(SH),Chen(... Fish Shellfish Immunol 2025-11-00

...HEXB), 14-3-3 protein 7 (TFT7), Rab GTPases (Rab1A, Rab11A), and vacuolar protein sorting-associated proteins (VPS11). P...

Xie(S),Huang(R),Qian(W),Ding(X),Zhang(W),L... Adv Sci (Weinh) 2025-11-00

...HEXB) is identified as the exclusive differentially expressed Gb3 synthase distinguishing these injury subtypes. Functio...