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Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by…

Higashi(S),Makiyama(T),Sakane(H),Nogami(S),S… J Cell Sci 2022-00-01

...Hook1, or Rab10 or Rab22a (which are both involved in Hook1-mediated endosomal sorting), attenuated the effect of γ-taxi...

Dynein activators and adaptors at a glance.

Olenick(MA),Holzbaur(ELF) J Cell Sci 2019-00-15

...Hook1 enhance the stability of the complex that dynein forms with its required activator dynactin, leading to highly pro...

The dynein adaptor Hook2 plays essential roles in mitotic progression and cytok…

Dwivedi(D),Kumari(A),Rathi(S),Mylavarapu(SVS… J Cell Biol 2019-00-04

...Hook1, Hook2, and Hook3, that have distinct subcellular localizations and expectedly, distinct cellular functions. Here ...

Incorporating Motility in the Motor: Role of the Hook Protein Family in Regulat…

Dwivedi(D),Chawla(P),Sharma(M) Biochemistry 2019-00-26

...HOOK1-HOOK3. This Perspective aims to provide an overview of the Hook protein structure and the cellular functions of Ho...

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes …

Olenick(MA),Dominguez(R),Holzbaur(ELF) J Cell Biol 2019-00-07

...Hook1 mediates transport of TrkB-BDNF-signaling endosomes in primary hippocampal neurons. Hook1 comigrates with a subpop...

Transcriptome-wide changes in testes reveal molecular differences in photoperio…

Sharma(A),Das(S),Kumar(V) Mol Reprod Dev 2019-00-00

...HOOK1, RGS2, PRDX4, BCL6, CYFIP2, PDCD4, P2RX4, and GABRA1) involved in gametogenesis and associated pathways. Overall, ...

A conserved interaction of the dynein light intermediate chain with dynein-dyna…

Lee(IG),Olenick(MA),Boczkowska(M),Franzini-A… Nat Commun 2018-00-07

...Hook1, Hook3, BICD2, and Spindly. A structure of the LIC1 helix bound to the N-terminal Hook domain reveals a conformati...

MeCP2 AT-Hook1 mutations in patients with intellectual disability and/or schizo…

Sheikh(TI),Harripaul(R),Ayub(M),Vincent(JB) Hum Mutat 2018-00-00

...Hook1 within the ID, in a large Pakistani family with childhood onset cognitive decline and schizophrenia (SCZ), de novo...

Hypoxia increases amyloid-β level in exosomes by enhancing the interaction betw…

Xie(JC),Ma(XY),Liu(XH),Yu(J),Zhao(YC),Tan(Y)… Am J Transl Res 2018-00-00

...Hook1 in SH-SY5YAPP695 cells. Moreover, hypoxia increased the interaction between amyloid precursor protein (APP) and CD...

Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality i…

Xu(M),Song(P),Huang(W),He(R),He(Y),Zhou(X),G… Biochim Biophys Acta Mol Basi… 2018-02-00

...hook1/y mutant male mice exhibited low locomotor activity, motor incoordination and cognitive deficit. In addition, thes...

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