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KRAS G12C inhibitors versus chemotherapy in second line and beyond in adults ...

Noordhof(A),Asmara(OD),de Jong(K),Gijtenbe... Cochrane Database Syst Rev 2026-02-17

...KRAS) G12C mutation.

MEK inhibitor-based genomically matched combinatorial targeted therapies in m...

Auckley(ED),Yohay(S),Ying(G),Szabo(A),Witt... Oncologist 2026-02-17

...KRAS alterations, treated with MEKi therapies between 2022-2024. Ten patients had KRAS G12R (34.5%), ten G12D (34.5%), a...

Clinical relevance of mosaic variants detected by exome sequencing.

Ghosh(R),Fazal(Z),Oler(AJ),Tokita(MJ),Lewi... J Allergy Clin Immunol 2026-05-00

...KRAS, and IDH2 were identified, demonstrating the potential for mosaic variant detection to inform treatment strategies....

Engineered Bacteria as living detectors of tumor DNA: A new diagnostic frontier.

Ghasemian(A),Al-Marzoqi(AH),Ali(ZA),Nouruz... Clin Chim Acta 2026-04-15

...KRAS mutations that drive many cancers. By leveraging natural competence and horizontal gene transfer, in combination wi...

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in p...

Bandi(DSR),Nagaraju(GP),Sarvesh(S),Foote(J... bioRxiv 2026-02-13

...KRASG12D and KRASG12C mutant PDAC cells resistant to allele-specific KRAS inhibitors. Oral administration of ADT-030 sig...

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endo...

Solomon(H),Mukherjee(R),Yang(YC),Meredith(... bioRxiv 2026-02-14

...KRAS co-mutations regrew after RMC-6272 treatment, which was prevented by the addition of the RAS(ON) multi-selective in...

The impact of p53 mutation on tumor immune evasion: mechanistic insights and ...

Liang(L),Wang(W) Front Immunol None

...KRAS co-mutant non-small cell lung cancer (NSCLC), Mtp53 enhances tumor immunogenicity and improves response to immune c...

Multi-omics comprehensive analysis identified KIF22 and KRAS as highly synthe...

Miao(S),Wang(X),Gu(Q),Bian(C),Fan(R),Ni(Q)... Front Oncol None

...KRAS as a synthetic lethal gene pair in TNBC. Functional experiments demonstrated that the knockdown of KIF22 in KRAS-mu...

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic C...

Kempinska(K),Mallett(CL),Pavlik(K),Kommara... J Vis Exp 2026-02-03

...Kras-driven, p53-deleted (KPC) mouse model of pancreatic ductal adenocarcinoma. This well-established clinically relevan...

Design, synthesis and biological evaluation of symmetric thiadiazole carboxam...

Cyriac(R),Lee(EJ),Kwon(Y),Yun(MR),Jung(ME)... Bioorg Med Chem Lett 2026-07-00

...KRAS and KEAP1 mutations, creating a dependency on glutaminase (GLS)-mediated glutaminolysis for survival and growth. Al...

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