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Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for H...

Xu(Ke),Ma(Lu),Li(Yang),Wang(Fang),Zheng(Gu... Hypertension 2015-11-05

...LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6 and their flanking sequences, in 3 Han Chinese cohorts consisting of 2630 patients...

Effects of bisphenol A and 4-nonylphenol on cellular responses through the di...

Dong(Yan),Araki(Mutsumi),Hirane(Miku),Tana... J Recept Signal Transduct R... 2015-01-07

...Lpar2. For cell motility assay with a Cell Culture Insert, cell motile activity of BPA-treated cells was significantly l...

Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and thei...

Brünnert(D),Sztachelska(M),Bornkessel(F),T... Mol Hum Reprod 2015-06-09

...LPAR2-6) mRNA was down-regulated after decidualization. We found that SPHK1 is highly expressed in HESCs, and is up-regu...

G-protein-coupled receptor signaling and polarized actin dynamics drive cell-...

Purvanov(Vladimir),Holst(Manuel),Khan(Jame... Elife 2015-07-28

...LPAR2) as a signal transducer specifically required for the actively invading cell during entosis. We find that G12/13 a...

Lysophosphatidic acid mediates fibrosis in injured joints by regulating colla...

Wu(L),Petrigliano(F A),Ba(K),Lee(S),Bogdan... Osteoarthritis Cartilage 2015-07-23

...LPAR2. LPA-induced increases in COL I production by chondrocytes and BMSCs were mediated by the MAP kinase and PI3 Kinas...

Lysophosphatidic acid receptor-2 deficiency confers protection against bleomy...

Huang(Long Shuang),Fu(Panfeng),Patel(Priya... Am J Respir Cell Mol Biol 2014-01-27

...Lpar2(-/-)) mice were protected against bleomycin-induced lung injury, fibrosis, and mortality, compared with wild-type ...

Inhibitory effects of LPA1 on cell motile activities stimulated by hydrogen p...

Hirane(Miku),Araki(Mutsumi),Dong(Yan),Hono... Biochem Biophys Res Commun 2014-01-14

...Lpar2 genes. To investigate the effects of LPA1 on the cell motile activity induced by hydrogen peroxide and DMNQ, Lpar1...

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteo...

David(Marion),Machuca-Gayet(Irma),Kikuta(J... J Biol Chem 2014-06-24

...Lpar2(-/-) and Lpar3(-/-) animals. Expression of LPA1 was up-regulated during osteoclastogenesis, and LPA1 antagonists (...

Growth of triple-negative breast cancer cells relies upon coordinate autocrin...

Hartman(Zachary C),Poage(Graham M),den Hol... Cancer Res 2014-01-02

...LPAR2-EZH2 NF-κB signaling cascade was essential for expression of interleukin (IL)-6, IL-8, and CXCL1. Concurrent inhib...

Altered lysophosphatidic acid (LPA) receptor expression during hepatic regene...

Simo(Kerri A),Niemeyer(David J),Hanna(Erin... HPB (Oxford) 2014-12-29

...LPAR2, LPAR4 and LPAR5 mRNA were barely detected in normal liver and did not significantly change after PHx. Changes in ...

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