Tecleab(Awet),Zhang(Xiaolei),Sebti(Said M) J Biol Chem 2015-01-17

...RalB, and sometimes RalA, but not AKT1/2 and c-Raf, to be required for maintaining low levels of p53 in human cancer cel...

Yan(Chao),Liu(Degang),Li(Liwei),Wempe(Mich... Nature 2015-01-13

The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. Chemicals that block Ral funct...

Popovic(Milica),Jakobi(Arjen J),Rensen-de ... J Struct Biol 2014-03-20

...RalB and couples Ras- to Ral-signalling. Here the crystal structure of the catalytic module of Rlf consisting of a REM- ...

Martin(Timothy D),Chen(Xiao-Wei),Kaplan(Re... Mol Cell 2014-04-11

...RalB-selective activation and Sec5- and exocyst-dependent engagement of mTORC1 and suppression of autophagy. Unexpectedl...

Cancer Discov 2014-11-10

...RalB pathway regulates mTORC1 activity independent of Rheb.

Mott(Helen R),Owen(Darerca) Biochem Soc Trans 2014-09-05

RLIP76 (Ral-interacting protein of 76 kDa) [also known as RalBP1 (Ral-binding protein 1)] is an effector for the Ral fam...

Chan(Nickie C),den Besten(Willem),Sweredos... J Biol Chem 2014-09-29

...RalB signaling, and cancer cell migration), its levels must be carefully regulated. Using quantitative mass spectrometry...

Seguin(Laetitia),Kato(Shumei),Franovic(Ale... Nat Cell Biol 2014-07-28

...RalB to the tumour cell plasma membrane, leading to the activation of TBK1 and NF-κB. In fact, α(v)β₃ expression and the...

Peschard(Pascal),McCarthy(Afshan),Leblanc-... Curr Biol 2013-05-23

...Ralb(+/-) embryos; embryos null for Rala and Ralb do not live past gastrulation. Using a Kras-driven non-small cell lung...

Martin(Timothy D),Der(Channing J) Small GTPases 2013-04-03

...RalB activation in CRC tumor cell lines and tumors. Surprisingly we found antagonistic roles for RalA and RalB in the re...