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Growth inhibitory effects of large subunit ribosomal proteins in melanoma.

Kardos(Gregory R),Dai(Mu-Shui),Robertson(G... Pigment Cell Melanoma Res 2016-05-16

...RPL5 and RPL11 binding to and preventing MDM2 from targeting p53 for degradation. The consequence was p53-dependent cell...

Post-transcriptional regulation of ribosomal protein genes during serum starv...

Ahamad(Jamaluddin),Ojha(Sandeep),Srivastav... Mol Biochem Parasitol 2016-06-07

...RPL5, RPL26, RPL30) representing the early-, mid-, and late-stages of ribosomal assembly. Transcripts of these genes per...

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupyin...

Calviño(Fabiola R),Kharde(Satyavati),Ori(A... Nat Commun 2016-04-05

During 60S biogenesis, mature 5S RNP consisting of 5S RNA, RpL5 and RpL11, assembles into a pre-60S particle, where dock...

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates...

Bailly(A),Perrin(A),Bou Malhab(L J),Pion(E... Oncogene 2016-06-20

...RPL5-Mdm2 pathway, with characteristics of nucleolar stress. The study identifies the nucleolus as a target of inhibitor...

Are Synonymous Substitutions in Flowering Plant Mitochondria Neutral?

Wynn(Emily L),Christensen(Alan C) J Mol Evol 2016-08-01

...rpl5 in most plant mitochondrial genomes, but in some genomes, rps14 has been duplicated to the nucleus leaving a pseudo...

Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozy...

Kazerounian(Shideh),Ciarlini(Pedro D S C),... J Cancer 2016-01-01

...Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 ge...

Dosage Sensitivity of RPL9 and Concerted Evolution of Ribosomal Protein Genes...

Devis(Deborah),Firth(Sue M),Liang(Zhe),Byr... Front Plant Sci 2016-01-06

...RPL5, RPL27a, RPL36a, and RPS6 family genes in the Brassicaceae indicated that multicopy ribosomal protein genes have be...

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synerg...

Devlin(Jennifer R),Hannan(Katherine M),Hei... Cancer Discov 2016-10-13

...RPL5. Thus, targeting the network controlling the synthesis and function of ribosomes at multiple points provides a pote...

Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripot...

Ge(Jingping),Apicella(Marisa),Mills(Jason ... PLoS One 2016-05-23

...RPL5 mutations. Transcriptome analysis revealed the striking dysregulation of the transforming growth factor β (TGFβ) si...

Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Pro...

Kamio(Takuya),Gu(Bai-wei),Olson(Timothy S)... PLoS One 2016-08-12

...RPL5 and RPL11, bind to MDM2. This inhibition, and the resulting increase in p53 levels has been proposed to be responsi...

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