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Genetic evidence prioritizes circulating proteins for heart failure beyond sh...

Su(CY),Lu(T) medRxiv 2026-06-22

...RSPO3 results did not support straightforward repurposing of existing pharmacological strategies.The prioritized protein...

Disentangling adiposity-related and non-adiposity-related genetic pathways fo...

Su(CY),Lu(T) medRxiv 2026-06-22

...RSPO3, GALNT3), and whole blood regulatory signals (PAM, SNUPN). Sixteen proteins were classified within druggable-genom...

High RSPO3 protein expression serves as an independent poor prognostic factor...

Jiang(S),Ma(H),Du(Z),Zhang(Y),Han(J),Ma(Z) Discov Oncol 2026-07-04

...RSPO3 was verified by knocking down RSPO3 in the co‑culture system, and further validation was carried out through Weste...

Deciphering the RSPO3-NFATC1 switch in the bone-cartilage paradox: Genetic li...

Peng(L),Wei(J),Yang(H),Qin(J),Li(Q) Osteoarthritis Cartilage 2026-05-30

...RSPO3 was upregulated in established OA cartilage. Single-cell analysis localized NFATC1 expression predominantly to ost...

Molecular cues from distinct neuron classes drive differential myelination in...

Domínguez-Iturza(N),Jokhi(V),Kim(K),Shetty... Dev Cell 2026-06-10

...Rspo3 promotes cortical myelination. This work provides a comprehensive molecular description of oligodendrocyte develop...

The Sex-Stratified Effects of RSPO3 Expression on Body Fat and Blood Lipids: ...

Guo(Y),Chen(Z),Huang(L),Zhang(Z),Gong(Y),Y... Obesity (Silver Spring) 2026-08-00

...RSPO3 protein levels, including three novel signals and four female-stratified loci. In women, RSPO3 protein levels were...

Aging disrupts hepatocyte zonation homeostasis in mice and humans.

Sinha(S),Ali(Q),Zhang(T),T-Nguyen(DH),Hann... Hepatology 2026-05-01

...Rspo3 signaling from non-parenchymal cells. To assess translational relevance, liver biopsies from young (≤25YO) and age...

Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with ...

Hartwich(TMP),Bellone(S),Tommasi(O),Ottum(... Int J Mol Sci 2026-08-22

...RSPO3, NOD1 and LRRK2. WES analysis of platinum-resistant IB-treated patients revealed additional nominally significant ...

Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular in...

Wang(M),Cai(H),Wang(M),Gao(H),Zhao(X),Rong... Phytomedicine 2025-07-25

...RSPO3) are targets of lonicerin. Lonicerin reduces high glucose-induced upregulation of ADRA1D and RSPO3, leading to dec...

Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease associa...

Zhou(C),Ruan(X),Che(T),Zhang(Y),Yuan(S),Li... Gastroenterol Rep (Oxf) 2025-00-00

...RSPO3) levels mediated the effects of body mass index (2.95%, 95% CI 0.18%-5.73%), body fat percentage (4.53%, 95% CI 1....

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