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Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical pept…

Tokareva(OS),Li(K),Travaline(TL),Thomson(TM)… Nat Commun 2023-00-01

...TEAD4), and a transcriptional coactivator (β-catenin).

Cellular proteins act as surfactants to control the interfacial behavior and fu…

Wang(Z),Yang(C),Guan(D),Li(J),Zhang(H) Dev Cell 2023-00-05

...TEAD4 are also regulated by the synergistic surfactant proteins RUNX3 and HOXA4. Our results indicate that the interfaci...

The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progressio…

Tang(J),Yang(Q),Mao(C),Xiao(D),Liu(S),Xiao(L… Cell Death Differ 2023-00-00

...TEAD4, through which YAP bind to DNA, activated UCHL3 transcription by binding to the promoter of UCHL3. In general, our...

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors.

Lu(W),Fan(M),Ji(W),Tse(J),You(I),Ficarro(SB)… J Med Chem 2023-00-13

...TEAD4 (TEF-3). Aberrant expression and hyperactivation of TEAD/YAP signaling have been implicated in a variety of malign...

Opposing gene regulatory programs governing myofiber development and maturation…

Dos Santos(M),Shah(AM),Zhang(Y),Bezprozvanna… Nat Commun 2023-00-19

...Tead4 form a transcriptional complex that synergistically activates the expression of muscle genes in developing myofibe...

HighPlay: Cyclic Peptide Sequence Design Based on Reinforcement Learning and Pr…

Lin(H),Zhu(C),Shang(T),Zhu(N),Lin(K),Zhang(C… J Med Chem 2025-06-12

...TEAD4 target exhibited micromolar-level affinity in further experimental validation.

A Fragment Screen Identifies Acrylamide Covalent Inhibitors of the TEAD•YAP Pro…

Bum-Erdene(K),Ghozayel(MK),Zhang(MJ),Gonzale… bioRxiv 2026-03-20

...TEAD4 binding to YAP. Synthesis of a focused set of derivatives and time- and concentration-dependent studies with four ...

An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore t…

Gao(X),Ren(C),Zhang(W),Fang(F) Reprod Domest Anim 2023-08-00

...TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identifie...

Platr4 is an early embryonic lncRNA that exerts its function downstream on card…

Hazra(R),Brine(L),Garcia(L),Benz(B),Chirathi… Dev Cell 2022-00-07

...Tead4 to regulate the expression of a downstream target gene, Ctgf, which is crucial to the cardiac-lineage program. Imp...

Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Assoc…

Man(QW),Ma(YQ),Liu(JY),Zhao(Y),Liu(B),Zhao(Y… Biomed Res Int 2017-00-00

...TEAD4, and RUNX2) and cell cycle related genes (CDK2, PCNA), which interact with the transcriptional coactivators YAP/TA...

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