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TRPC3 regulates release of brain-derived neurotrophic factor from human airwa...

Vohra(Pawan K),Thompson(Michael A),Sathish... Biochim Biophys Acta 2014-02-24

...Orai1 or plasma membrane caveolin-1. Functionally, secreted BDNF had autocrine effects suggested by phosphorylation of h...

Characterization of store-operated Ca2+ channels in pancreatic duct epithelia...

Kim(Mean-Hwan),Seo(Jong Bae),Burnett(Linds... Cell Calcium 2014-05-27

...Orai1 proteins in PDEC, we confirmed that colocalization of the two proteins increases after store depletion. In conclus...

Orai1 and transient receptor potential channels as novel molecular targets to...

Moccia(Francesco),Dragoni(Silvia),Poletto(... Anticancer Agents Med Chem 2014-10-11

...Orai1 provide the pathway for such proangiogenic Ca(2+) signal. In addition, Canonical TRP 1 (TRPC1) and Orai1 channels ...

Urotensin-II promotes vascular smooth muscle cell proliferation through store...

Rodríguez-Moyano(María),Díaz(Ignacio),Dion... Cardiovasc Res 2014-07-01

...Orai1, and TRPC1. Co-immunoprecipitation experiments showed that UII promoted the association between Orai1 and STIM1, a...

Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, ...

Lang(Florian),Stournaras(Christos) Hormones (Athens) 2014-03-10

...Orai1/STIM1, ROMK, KCNE1/KCNQ1, GluR6, CFTR). SGK1 further up-regulates a number of enzymes (e.g. glycogen-synthase-kina...

The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated ...

Ashmole(Ian),Duffy(S Mark),Leyland(Mark L)... PLoS One 2014-07-01

...Orai1 plays an important role in Ca(2+) influx and mediator release from HLMCs. Strategies which target Orai1 will effec...

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium...

Stathopulos(Peter B),Schindl(Rainer),Fahrn... Nat Commun 2014-07-06

...Orai1 currents. CC2 mutations cause remarkable variability in Orai1 activation because of a dual function in binding Ora...

Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells...

Ross(Diana G F),Smart(Chanel E),Azimi(Iman... BMC Cell Biol 2014-06-16

...ORAI1, has been suggested as a potential mechanism for the entry of Ca(2+) into mammary gland epithelial cells from the ...

Orai1-dependent calcium entry promotes skeletal muscle growth and limits fati...

Wei-Lapierre(Lan),Carrell(Ellie M),Boncomp... Nat Commun 2014-07-15

...Orai1 (dnOrai1) and demonstrate that Orai1-dependent SOCE promotes growth and limits fatigue in adult skeletal muscle. d...

Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell func...

Cox(Jennifer H),Hussell(Scott),Søndergaard... PLoS One 2014-10-06

...Orai1 monoclonal antibody (mAb) against an extracellular loop of the plasma membrane-spanning protein. The anti-Orai1 mA...

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