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A high-throughput, cell-based screening method for siRNA and small molecule i...

Hoffman(Gregory R),Moerke(Nathan J),Hsia(M... Assay Drug Dev Technol 2010-07-21

...rpS6-phosphorylation as a measure of mTORC1 signaling. This assay takes advantage of the "In Cell Western" (ICW) techniq...

The translation regulatory subunit eIF3f controls the kinase-dependent mTOR s...

Csibi(Alfredo),Cornille(Karen),Leibovitch(... PLoS One 2010-09-30

...rpS6. During terminal muscle differentiation a conserved TOS motif in eIF3f connects mTOR/raptor complex, which phosphor...

Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Black...

Doherty(Leana),Sheen(Mee Rie),Vlachos(Adri... Am J Hum Genet 2010-03-19

...RPS6, RPL27A, RPLP2, RPS25, RPS3, RPL41, RPL6, RPLP0, RPS26, RPL21, RPL36AL, RPS29, RPL4, RPLP1, RPL13, RPS15A, RPS2, an...

Translational signaling responses preceding resistance training-mediated myof...

Mayhew(David L),Kim(Jeong-Su),Cross(James ... J Appl Physiol (1985) 2010-01-13

...RPS6), eukaryotic initiation factor 4E (eIF4E) binding protein (4EBP1), eIF4E, and eIF4G were all elevated (23-199%) 24 ...

EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypo...

Ji(Ruyue),Chou(Chih-Ling),Xu(Wei),Chen(Xia... Mol Pharmacol 2010-06-01

...rpS6), suggesting activation of the ribosomal S6 kinases and increased translation. Stimulation of endogenous EP1 recept...

Human chorionic gonadotropin stimulates theca-interstitial cell proliferation...

Palaniappan(Murugesan),Menon(K M J) Mol Endocrinol 2010-12-22

...rpS6. Pharmacological inhibition of ERK1/2 signaling did not block the hCG-induced phosphorylation of tuberin, the upstr...

Nucleus accumbens core mammalian target of rapamycin signaling pathway is cri...

Wang(Xi),Luo(Yi-xiao),He(Ying-ying),Li(Fan... J Neurosci 2010-10-08

...rps6), measures of mTOR activity, in the nucleus accumbens (NAc) core but not shell. Furthermore, inhibition of NAc core...

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-lik...

Potratz(Jenny C),Saunders(Darren N),Wai(Da... Cancer Res 2010-12-21

...RPS6); (b) that BMS-536924 fails to block RPS6 activation in resistant sarcoma cell lines; and (c) that siRNA knockdown ...

Stabilization and activation of p53 downregulates mTOR signaling through AMPK...

Drakos(E),Atsaves(V),Li(J),Leventaki(V),An... Leukemia 2009-05-04

...rpS6. Pharmacologic inhibition of AMPK using compound C in nutlin-3A-treated MCL cells harboring wt-p53 did not affect t...

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithel...

Trinh(X B),Tjalma(W A A),Vermeulen(P B),Va... Br J Cancer 2009-04-01

...RPS6 and the VEGFR2 gene, which is consistent as the gene expression and phosphorylation of S6 is inversely regulated. A...

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